High prevalence of clonal monoallelic expression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Genetics"
DOI: 10.1038/s41588-018-0188-7
Abstract: To the Editor — In recent years, there has been substantial interest in clonally stable monoallelic expression of autosomal genes in mammalian cells. This ‘autosomal analog of X-chromosome inactivation’ has been observed to affect hundreds… read more here.
Keywords: analysis; expression; arme; monoallelic expression ... See more keywords
Three intronic lncRNAs with monoallelic expression derived from the MEG8 gene in cattle
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DOI: 10.1111/age.12527
Abstract: The field of long noncoding RNA (lncRNA) research has been rapidly advancing in recent years. Antisense lncRNAs, intergenetic lncRNAs and enhancer lncRNAs can regulate genomic imprinting, which leads to parent-origin-specific monoalletic expression of genes. However,… read more here.
Keywords: rna; meg8 intronic; meg8 gene; expression ... See more keywords
Monoallelic expression in melanoma
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DOI: 10.1186/s12967-019-1863-x
Abstract: BackgroundMonoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of a gene that is restricted to… read more here.
Keywords: melanoma; cell lines; mae; rate ... See more keywords
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
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DOI: 10.1371/journal.pcbi.1008772
Abstract: Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic and allele-biased expression observed… read more here.
Keywords: monoallelic expression; transcriptional bursting; transcriptional bursts; expression ... See more keywords
The Evolutionary Advantage in Mammals of the Complementary Monoallelic Expression Mechanism of Genomic Imprinting and Its Emergence From a Defense Against the Insertion Into the Host Genome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.832983
Abstract: In viviparous mammals, genomic imprinting regulates parent-of-origin-specific monoallelic expression of paternally and maternally expressed imprinted genes (PEGs and MEGs) in a region-specific manner. It plays an essential role in mammalian development: aberrant imprinting regulation causes… read more here.
Keywords: complementary monoallelic; monoallelic expression; genomic imprinting; expression ... See more keywords