The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05648-z
Abstract: RATIONALE The nonmedical use of new psychoactive substances (NPS) is a worldwide public health concern. The so-called "benzofury" compounds, 5-(2-aminopropyl)benzofuran (5-APB) and 6-(2-aminopropyl)benzofuran (6-APB), are NPS with stimulant-like properties in human users. These substances are… read more here.
Keywords: male rats; apb apb; monoamine; monoamine transmission ... See more keywords
Low thalamic monoamine transporter availability is related to excessive daytime sleepiness in early Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Sciences"
DOI: 10.1007/s10072-019-04206-6
Abstract: Although excessive daytime sleepiness (EDS) is a frequent non-motor dysfunction in Parkinson’s disease (PD), the exact pathophysiology remains elusive. This study investigates the relationship between daytime sleepiness and presynaptic monoamine transporter densities of the basal… read more here.
Keywords: excessive daytime; monoamine; daytime sleepiness; parkinson disease ... See more keywords
The Effects of Chronic Amitriptyline on Zebrafish Behavior and Monoamine Neurochemistry
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2536-5
Abstract: Amitriptyline is a commonly used tricyclic antidepressant (TCA) inhibiting serotonin and norepinephrine reuptake. The exact CNS action of TCAs remains poorly understood, necessitating new screening approaches and novel model organisms. Zebrafish (Danio rerio) are rapidly… read more here.
Keywords: amitriptyline zebrafish; effects chronic; behavior monoamine; monoamine ... See more keywords
Amino bearing core-shell structured magnetic covalent organic framework nanospheres: Preparation, postsynthetic modification with phenylboronic acid and enrichment of monoamine neurotransmitters in human urine.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.09.078
Abstract: Covalent organic frameworks (COFs) have been increasingly employed in separation science, including sample preparation. Herein we fabricated the amino bearing core-shell structured COFs nanospheres [Fe3O4@TpBD(NH2)2], and a novel magnetic boronate affinity adsorbent was synthesized by… read more here.
Keywords: shell structured; core shell; monoamine; monoamine neurotransmitters ... See more keywords
An investigation of the single and combined effects of hypogravity and ionizing radiation on brain monoamine metabolism and rats' behavior.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences in space research"
DOI: 10.1016/j.lssr.2018.11.003
Abstract: BACKGROUND Ionizing radiation and hypogravity can cause central nervous system (CNS) dysfunctions. This is a key limiting factor for deep space missions. Up until now, the mechanisms through which they affect the neural tissue are… read more here.
Keywords: metabolism; ionizing radiation; monoamine; brain ... See more keywords
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.003
Abstract: Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to… read more here.
Keywords: protein; mao levels; mao; monoamine ... See more keywords
Fluorogenic Detection of Monoamine Neurotransmitters in Live Cells.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00391
Abstract: Monoamine neurotransmission is key to neuromodulation, but imaging monoamines in live neurons has remained a challenge. Here we show that externally added ortho-phthalaldehyde (OPA) can permeate live cells and form bright fluorogenic adducts with intracellular… read more here.
Keywords: neurotransmitters live; live cells; detection monoamine; fluorogenic detection ... See more keywords
Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00228
Abstract: Monoamine oxidase B (MAO-B) metabolizes monoamines such as dopamine regarding neural transmission and controls its level in the mammalian's brain. When MAO-B metabolizes dopamine abnormally, normal neurotransmission does not occur, and central nervous system disorders… read more here.
Keywords: mao; monoamine; inhibitory activity; arylated heliamine ... See more keywords
Classic Monoamine Oxidase Inhibitors for Depression: Update on Nursing Care
Sign Up to like & getrecommendations! Published in 2022 at "Issues in Mental Health Nursing"
DOI: 10.1080/01612840.2022.2149908
Abstract: Severe, ‘treatment-resistant’ depressions may respond to treatment with a classic monoamine oxidase inhibitor (MAOI) even when myriad trials with other antidepressant classes have failed (Bodkin & Dunlop, 2021). These drugs have a unique pharmacological profile… read more here.
Keywords: classic monoamine; effect; monoamine; monoamine oxidase ... See more keywords
Edible insects prevent changes to brain monoamine profiles from malnourishment in weaned rats.
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2022.2104692
Abstract: Background: Childhood malnutrition can have devastating consequences on health, behavior, and cognition. Edible insects are sustainable low cost high protein and iron nutritious foods that can prevent malnutrition. However, it is unclear whether insect-based diets… read more here.
Keywords: monoamine; insects; brain; malnutrition ... See more keywords
Did you know? Dopamine, pop culture and beyond
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13971
Abstract: The everincreasing consumption of social media shapes the perception and worldview of the vast majority of the public in modern societies.1 This fastpaced virtual space has recently seen a relative increase in popularity of shortform,… read more here.
Keywords: culture; monoamine; dopamine; physiology ... See more keywords