Hormonal Contraception and Its Association With Depression.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3701
Abstract: Hormonal Contraception and Its Association With Depression To the Editor Skovlund and colleagues1 wrote that depression is hitherto a relatively unnoticed adverse effect of hormonal contraceptives. Depressive mood changes are important reasons for discontinuing use… read more here.
Keywords: depression; contraception association; monoamine oxidase; association depression ... See more keywords
Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase‐B inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200084
Abstract: The conceptual layout of monoamine oxidase (MAO) inhibitors has been modified to explore their potential biological application in the case of neurological disorders for the time being. The current review article is an effort to… read more here.
Keywords: monoamine oxidase; role benzyloxy;
Identification of 7,8‐dihydroxy‐3‐phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22651
Abstract: We herein report the biological evaluation of 3‐arylcoumarin derivatives (3a‐l) as potential human monoamine oxidase‐A and ‐B (hMAO‐A and hMAO‐B) inhibitors. The result indicated that 7,8‐dihydroxy‐3‐(4‐nitrophenyl)coumarin (3j) was most effective against MAO‐A (inhibition concentration [IC50] = 6.46 ± 0.02 µM)… read more here.
Keywords: hmao enzymes; hmao; identification dihydroxy; monoamine oxidase ... See more keywords
Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01927-w
Abstract: Monoamine oxidase (MAO) type B (MAO-B) inhibition was shown to confer anti-parkinsonian benefit as monotherapy and adjunct to l-3,4-dihydroxyphenylalanine (l-DOPA) in clinical trials. Here, we explore the anti-parkinsonian effect of MAO type A (MAO-A) inhibition… read more here.
Keywords: mao; anti parkinsonian; monoamine oxidase; monotherapy ... See more keywords
Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1709-8
Abstract: Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. In depressive disorders, increase in MAOA expression and decrease… read more here.
Keywords: type monoamine; depressive disorders; impaired neurogenesis; monoamine oxidase ... See more keywords
Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0030-1
Abstract: Both monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson’s disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and… read more here.
Keywords: mao; monoamine oxidase; iron; activity ... See more keywords
Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3429-2
Abstract: The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2D3), was reported to improve vascular function in patients with diabetes, yet the underlying mechanisms remain to be fully elucidated. Monoamine oxidase (MAO), a mitochondrial enzyme, with two… read more here.
Keywords: vascular function; monoamine oxidase; expression; experimental diabetes ... See more keywords
The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10143-w
Abstract: Abstract Monoamine oxidase (MAO) is of much clinical relevance, and inhibitors of this enzyme are used in the treatment for neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease. The present study synthesises and… read more here.
Keywords: chromanone derivatives; tetralone chromanone; mao; monoamine oxidase ... See more keywords
Design and synthesis of novel benzyloxy-tethered-chromone-carboxamide derivatives as potent and selective human monoamine oxidase-b inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01332-w
Abstract: A series of new bifunctional 7-benzyloxy-2, 3-dimethyl-4-oxo-4H-chromene-8-carboxamides 5a - 5 l were synthesized from 7-hydroxy 2,3 dimethyl chromone via key intermediate 7-benzyloxy 2,3 dimethyl-8-carboxylic acid using Jones oxidation and HBTU/HOBt (Hexafluorophosphate Benzotriazole Tetramethyl Uronium/Hydroxybenzotriazole) as selective… read more here.
Keywords: benzyloxy; human monoamine; chromone; monoamine oxidase ... See more keywords
Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase‐A and ‐B
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.06.024
Abstract: Graphical abstract Figure. No caption available. &NA; The endocannabinoid system plays an important role in the pathophysiology of various neurological disorders, such as anxiety, depression, neurodegenerative diseases, and schizophrenia; however, little information is available on… read more here.
Keywords: virodhamine; inhibition mao; mao; monoamine oxidase ... See more keywords
Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.051
Abstract: Three flavanones and two flavones were isolated from the leaves of Prunus padus var. seoulensis by the activity-guided screening for new monoamine oxidase (MAO) inhibitors. Among the compounds isolated, rhamnocitrin (5) was found to potently… read more here.
Keywords: padus var; monoamine oxidase; hmao hmao; var seoulensis ... See more keywords