Monoamine Transporters as Ionotropic Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.02.003
Abstract: It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity… read more here.
Keywords: ionotropic receptors; transporters ionotropic; monoamine transporters;
In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine Transporters
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DOI: 10.1021/acsomega.2c02714
Abstract: New psychoactive substances (NPS) are a group of compounds that mimic the effects of illicit substances. A range of NPS have been shown to interact with the three main classes of monoamine transporters (DAT, NET,… read more here.
Keywords: silico investigations; psychoactive substances; investigations selectivity; new psychoactive ... See more keywords
Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside binding to an allosteric site in monoamine transporters
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1018473
Abstract: Albizia julibrissin Durazz is one of the most common herbs used for depression and anxiety treatment, but its mechanism of action as an antidepressant or anxiolytic drug have not been fully understood. We previously isolated… read more here.
Keywords: molecular docking; monoamine; allosteric site; monoamine transporters ... See more keywords
Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3
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DOI: 10.3390/biom12101507
Abstract: Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine derivatives… read more here.
Keywords: membrane transport; derivatives human; stereoselectivity; transport ... See more keywords