Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
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DOI: 10.1002/iub.2668
Abstract: Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the “Warburg effect”. To accommodate the high glucose demands and to avoid… read more here.
Keywords: structural aspects; warburg effect; monocarboxylate transporters; aspects glucose ... See more keywords
Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice
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DOI: 10.14814/phy2.15457
Abstract: The concept of lactate shuttle is widely accepted in exercise physiology. Lactate transport is mediated by monocarboxylate transporters (MCT), which enable cells to take up and release lactate. However, the role of lactate during exercise… read more here.
Keywords: transporters mct; inhibition; lactate; monocarboxylate transporters ... See more keywords
Candidate genes for performance in horses, including monocarboxylate transporters
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DOI: 10.1590/s0100-736x2017000100011
Abstract: Some horse breeds are highly selected for athletic activities. The athletic potential of each animal can be measured by its performance in sports. High athletic performance depends on the animal capacity to produce energy through… read more here.
Keywords: performance horses; candidate genes; performance; monocarboxylate transporters ... See more keywords
Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications
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DOI: 10.3389/fcell.2022.1069555
Abstract: The Warburg effect is known as the hyperactive glycolysis that provides the energy needed for rapid growth and proliferation in most tumor cells even under the condition of sufficient oxygen. This metabolic pattern can lead… read more here.
Keywords: tumor cells; coupled monocarboxylate; proton coupled; monocarboxylate transporters ... See more keywords
Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma
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DOI: 10.3390/cancers14051298
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a five-year survival rate of read more here.
Keywords: pancreatic ductal; extracellular matrix; ductal adenocarcinoma; monocarboxylate transporters ... See more keywords
Monocarboxylate Transporters 1 and 4 and Prognosis in Small Bowel Neuroendocrine Tumors
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DOI: 10.3390/cancers14102552
Abstract: Simple Summary Monocarboxylate transporters (MCT) are cell membrane proteins transporting lactate, pyruvate, and ketone bodies. For most non-neoplastic cells, the aforementioned energy metabolites are waste products and must be exported via MCTs. However, it seems… read more here.
Keywords: small bowel; bowel neuroendocrine; neuroendocrine tumors; monocarboxylate transporters ... See more keywords