Switching Heavy Chain Constant Domains Denatures the Paratope 3D Architecture of Influenza Monoclonal Antibodies
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DOI: 10.3390/pathogens12010051
Abstract: Several human monoclonal Abs for treating Influenza have been evaluated in clinical trials with limited success despite demonstrating superiority in preclinical animal models including mice. To conduct efficacy studies in mice, human monoclonal Abs are… read more here.
Keywords: heavy chain; mouse; constant domains; chain constant ... See more keywords