Estimated Health Outcomes and Costs Associated With Use of Monoclonal Antibodies for Prevention or Mitigation of SARS-CoV-2 Infections
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.5750
Abstract: This economic evaluation investigates the health outcomes and costs associated with use of monoclonal antibodies for treatment of SARS-CoV-2 in 14 scenarios stratified by age, vaccination status, and source of infection. read more here.
Keywords: associated use; health outcomes; outcomes costs; costs associated ... See more keywords
Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14606
Abstract: Autoimmune coagulation factor XIII (FXIII) deficiency (AiF13D) is a bleeding disorder caused by anti‐FXIII autoantibodies. Recently, we generated human monoclonal antibodies (mAbs) from the peripheral blood of an AiF13D patient and classified them into three… read more here.
Keywords: factor xiii; monoclonal antibodies; human monoclonal; deficiency ... See more keywords
Characterization and epitope mapping of a panel of monoclonal antibodies against HIV‐1 matrix protein
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DOI: 10.1002/bab.1662
Abstract: The HIV‐1 Gag precursor protein (p55) is the main structural protein comprising the matrix (MA/p17), capsid (CA/p24), and nucleocapsid (NC/p7) proteins, and is uniquely responsible for virion assembly within the virus life cycle. The MA… read more here.
Keywords: protein; virion; monoclonal antibodies; panel monoclonal ... See more keywords
Development and characterization of anti‐HPV16 monoclonal antibodies for assembly of an HPV16 detection kit
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2384
Abstract: Quality control is very important during the development of 3‐valent (16/18/58), 9‐valent (6/11/16/18/31/33/45/52/58), and 15‐valent human papillomavirus (HPV) vaccines (6/11/16/18/31/33/35/39/45/52/56/58/59/68). All 3‐valent, 9‐valent, and 15‐valent HPV vaccines contain the HPV16 antigen; therefore, a detection method… read more here.
Keywords: detection kit; hpv16 detection; development; valent valent ... See more keywords
An integrated modular framework for modeling the effect of ammonium on the sialylation process of monoclonal antibodies produced by CHO cells
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Journal"
DOI: 10.1002/biot.202100019
Abstract: Monoclonal antibodies (mABs) have emerged as one of the most important therapeutic recombinant proteins in the pharmaceutical industry. Their immunogenicity and therapeutic efficacy are influenced by post‐translational modifications, specifically the glycosylation process. Bioprocess conditions can… read more here.
Keywords: integrated modular; modular framework; monoclonal antibodies; process ... See more keywords
Strategies for Controlling Afucosylation in Monoclonal Antibodies during Upstream Manufacturing.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200604
Abstract: Core fucosylation is a highly prevalent and significant feature of N-glycosylation in therapeutic monoclonal antibodies produced by mammalian cells where its absence (afucosylation) plays a key role in treatment safety and efficacy. Notably, even slight… read more here.
Keywords: afucosylation; upstream manufacturing; strategies controlling; controlling afucosylation ... See more keywords
Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28120
Abstract: In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density… read more here.
Keywords: pilot scale; acid sensitive; monoclonal antibodies; integrated continuous ... See more keywords
Real‐world evidence following a mandatory treatment break after a 1‐year prophylactic treatment with calcitonin gene‐related peptide (pathway) monoclonal antibodies
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DOI: 10.1002/brb3.2662
Abstract: Current German and European guidelines suggest migraine patients undertake a treatment break after 9 to 12 months of treatment with CGRP (pathway) monoclonal antibodies. read more here.
Keywords: pathway monoclonal; world evidence; treatment break; treatment ... See more keywords
Evaluating Multi-Product Chromatography Protein A Reuse for Monoclonal Antibodies In Biopharmaceutical Manufacturing.
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DOI: 10.1002/btpr.3333
Abstract: In good manufacturing practice (GMP) facilities in the biopharmaceutical industry, chromatography resins are largely underutilized during purification of single drug products during clinical production. Chromatography resins are dedicated to a specific product and disposed of,… read more here.
Keywords: product; carryover; chromatography; monoclonal antibodies ... See more keywords
Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24468
Abstract: α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these inclusions, α‐syn is phosphorylated at the serine‐129 residue. Antibodies directed to this phosphorylation… read more here.
Keywords: monoclonal antibodies; ps129 syn; syn; sensitivity specificity ... See more keywords
Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249841
Abstract: Effective vaccines and monoclonal antibodies have been developed against coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However, the appearance of virus variants with higher transmissibility and pathogenicity is a… read more here.
Keywords: omicron variant; omicron; vaccination; variant ... See more keywords