Uveal Effusion After Immune Checkpoint Inhibitor Therapy
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.0920
Abstract: Importance Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include… read more here.
Keywords: uveal effusion; immune checkpoint; anti monoclonal; therapy ... See more keywords
Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13791
Abstract: Neurofibrillary tangles formed by abnormally aggregated tau protein are a histopathological feature of tauopathies. A tau aggregation inhibitor is a potential therapeutic agent for tauopathies. In this study, we prepared a monoclonal antibody for tau,… read more here.
Keywords: tau aggregation; crystal structure; domain; monoclonal antibody ... See more keywords
Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13410
Abstract: Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain,… read more here.
Keywords: monoclonal antibody; diabetic neuralgia; nerve growth; growth factor ... See more keywords
PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab
Sign Up to like & getrecommendations! Published in 2023 at "Birth Defects Research"
DOI: 10.1002/bdr2.2169
Abstract: Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. In order to support use of Lartruvo in pediatric patients, a definitive juvenile animal study in neonatal mice was conducted with a… read more here.
Keywords: pdgfr monoclonal; monoclonal antibody; antibody assessment; mice ... See more keywords
Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201700133
Abstract: Achieving consistent product quality of a biotherapeutic is a major target for any biopharmaceutical manufacturer, even more for a biosimilar producer as comparability with the innovator product is a regulatory expectation. The complexity of biotherapeutic… read more here.
Keywords: chromatographic platform; integrated chromatographic; charge; separation ... See more keywords
CGRP monoclonal antibody for preventive treatment of chronic migraine: An update of meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1215
Abstract: CGRP monoclonal antibody (mAb) is a promising preventive treatment for episodic migraine and has been approved by US FDA recently. But the treatments for chronic migraine are rare. Therefore, we performed meta‐analysis to assess the… read more here.
Keywords: migraine; meta analysis; chronic migraine; preventive treatment ... See more keywords
Design and operation of a continuous integrated monoclonal antibody production process
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2522
Abstract: The realization of an end‐to‐end integrated continuous lab‐scale process for monoclonal antibody manufacturing is described. For this, a continuous cultivation with filter‐based cell‐retention, a continuous two column capture process, a virus inactivation step, a semi‐continuous… read more here.
Keywords: monoclonal antibody; process; steady state; operation ... See more keywords
Adapting virus filtration to enable intensified and continuous monoclonal antibody processing
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Progress"
DOI: 10.1002/btpr.3088
Abstract: Ongoing efforts in the biopharmaceutical industry to enhance productivity and reduce manufacturing costs include development of intensified, linked, and/or continuous processes. One approach to improve productivity and process economics of the polishing step (i.e., anion… read more here.
Keywords: filtration; step; virus filtration; concentration ... See more keywords
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3231
Abstract: Virus removal filtration is a critical step in the manufacture of monoclonal antibody products, providing a robust size‐based removal of both enveloped and non‐enveloped viruses. Many monoclonal antibodies show very large reductions in filtrate flux… read more here.
Keywords: monoclonal antibody; filtrate flux; filtration; role membrane ... See more keywords
Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.784
Abstract: BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclonal antibody. In this study the pharmacokinetics and target engagement (TE) of BMS‐986184 in healthy participants were characterized using population‐based target‐mediated drug disposition (TMDD) modeling and… read more here.
Keywords: bms 986184; healthy participants; interferon induced; pharmacokinetics target ... See more keywords
Monitoring bioactive and total antibody concentrations for continuous process control by surface plasmon resonance spectroscopy
Sign Up to like & getrecommendations! Published in 2019 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201900014
Abstract: Monoclonal antibodies have become an increasingly important part of fundamental research and medical applications. To meet the high market demand for monoclonal antibodies in the biopharmaceutical sector, industrial manufacturing needs to be achieved by large… read more here.
Keywords: antibody concentrations; antibody; spectroscopy; surface plasmon ... See more keywords