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   Articles with "monocrotaline induced" as a keyword



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Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

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recommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22353

Abstract: For 22 days after monocrotaline injection two groups of rats received either of the monocarbonyl curcumin analogs (2E,6E)‐2,6‐bis(2‐bromobenzylidene)cycloxehanone (B2BrBC) and (2E,6E)‐2,6‐bis([2‐trifluoromethyl]benzylidene)cyclohexanone (C66), and their right ventricle parameters were compared to those from the control and… read more here.

Keywords: monocrotaline; curcumin analogs; b2brbc c66; monocarbonyl curcumin ... See more keywords
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Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.

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recommendations! Published in 2019 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2019.172777

Abstract: Novel pharmacological approaches are needed to improve outcomes of patients with idiopathic pulmonary hypertension. Rho-associated protein kinase (ROCK) inhibitors have shown beneficial effects in preclinical models of pulmonary arterial hypertension (PAH), because of their role… read more here.

Keywords: inhibitor; arterial hypertension; pulmonary arterial; monocrotaline induced ... See more keywords
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Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.

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recommendations! Published in 2020 at "Journal of cardiology"

DOI: 10.1016/j.jjcc.2020.12.009

Abstract: BACKGROUND The receptor for advanced glycation end products (RAGE), a transmembrane receptor belonging to the immunoglobulin superfamily, is overexpressed in pulmonary artery smooth muscle cells (PASMCs) in patients with pulmonary arterial hypertension (PAH) and is… read more here.

Keywords: continuous subcutaneous; monocrotaline induced; rage aptamer; aptamer ... See more keywords
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Arctigenin prevents monocrotaline-induced pulmonary arterial hypertension in rats

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recommendations! Published in 2019 at "RSC Advances"

DOI: 10.1039/c8ra07892k

Abstract: Arctigenin ameliorates monocrotaline-induced pulmonary arterial hypertension, at least in part, through exerting its anti-inflammatory, antioxidant, and antiproliferative effects, which inhibit the NLRP3 inflammasome signal pathway in rats. read more here.

Keywords: arctigenin prevents; monocrotaline induced; pulmonary arterial; arterial hypertension ... See more keywords

Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.

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recommendations! Published in 2019 at "Congenital heart disease"

DOI: 10.1111/chd.12733

Abstract: OBJECTIVE This study explores the role of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension (PH) using rat models. METHOD Sprague Dawley rats (n = 45) were randomly grouped into normal group, control group, and model group.… read more here.

Keywords: group; hes5 signal; monocrotaline induced; signal pathway ... See more keywords
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Cystamine slows but not inverses the progression of monocrotaline-induced pulmonary arterial hypertension in rats.

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recommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"

DOI: 10.1139/cjpp-2017-0720

Abstract: Tissue transglutaminase (TG2) plays an important role in pulmonary arterial hypertension (PAH). Previous research indicate that TG2 and protein serotonylation catalyzed by TG2 are upregulated in PAH. Serotonin transporter inhibitor fluoxetine ameliorates PAH via inhibition… read more here.

Keywords: monocrotaline; tg2; pulmonary arterial; monocrotaline induced ... See more keywords
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Monocrotaline-Induced Pulmonary Arterial Hypertension and Bosentan Treatment in Rats: Focus on Plasma and Erythrocyte Parameters

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15101227

Abstract: The objective of our study was to contribute to the characterization of monocrotaline-induced pulmonary arterial hypertension (PAH) in a rat model, with emphasis on the renin–angiotensin–aldosterone system, parameters of oxidative stress, the activity of matrix… read more here.

Keywords: arterial hypertension; erythrocyte parameters; pulmonary arterial; induced pulmonary ... See more keywords