Endogenous secretory leukocyte protease inhibitor inhibits microbial‐induced monocyte activation
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DOI: 10.1002/eji.202249964
Abstract: In the intestine, epithelial factors condition incoming immune cells including monocytes to adapt their threshold of activation and prevent undesired inflammation. Colonic epithelial cells express Secretory Leukocyte Protease Inhibitor (SLPI), an inhibitor of NF kappa… read more here.
Keywords: slpi; monocyte activation; inhibitor; leukocyte protease ... See more keywords
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx108
Abstract: Abstract Background Increased monocyte activation and intestinal damage have been shown to be predictive for the increased morbidity and mortality observed in treated people living with human immunodeficiency virus (PLHIV). Methods A cross-sectional analysis of… read more here.
Keywords: inflammation; hiv negative; activation; monocyte activation ... See more keywords
Receptor-interacting protein kinase 3 mediates macrophage/monocyte activation in autoimmune hepatitis and regulates interleukin-6 production
Sign Up to like & getrecommendations! Published in 2018 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640618756124
Abstract: Background The mechanisms of macrophages/monocytes in autoimmune hepatitis (AIH) remain unclear. We investigated the role of receptor-interacting protein kinase 3 (RIP3), a key inflammatory signal adapter, in macrophage/monocyte activation in AIH. Methods Liver tissues and… read more here.
Keywords: monocyte activation; production; aih; activation ... See more keywords
HbS promotes TLR4-mediated monocyte activation and pro-inflammatory cytokine production in sickle cell disease.
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DOI: 10.1182/blood.2021014894
Abstract: Monocytes are considered crucial actors of inflammation in sickle cell disease (SCD), being responsible for an increased production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Although a role of free heme released by… read more here.
Keywords: monocyte activation; sickle cell; hbs; production ... See more keywords
Cardiac strain is lower among women with HIV in relation to monocyte activation
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DOI: 10.1371/journal.pone.0279913
Abstract: Background Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited. Setting Massachusetts General Hospital, Boston, Massachusetts. Methods… read more here.
Keywords: heart failure; gls; monocyte activation; lower gls ... See more keywords
Regulation of monocyte activation by PPARα through interaction with the cGAS-STING pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.2337/db22-0654
Abstract: Monocyte activation plays an important role in diabetic complications such as diabetic retinopathy (DR). However, the regulation of monocyte activation in diabetes remains elusive. Fenofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPARα), has shown robust… read more here.
Keywords: cgas sting; activation; ppar knock; monocyte activation ... See more keywords
Analyzing Inter-Leukocyte Communication and Migration In Vitro: Neutrophils Play an Essential Role in Monocyte Activation During Swarming
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DOI: 10.3389/fimmu.2021.671546
Abstract: Neutrophils are known to be the first responders to infection or injury. However, as inflammation progresses, other leukocytes become increasingly important in inflammation propagation, tissue reconstruction, and inflammation resolution. In recent years, there has been… read more here.
Keywords: inflammation; neutrophils play; migration; play essential ... See more keywords
Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients
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DOI: 10.3390/biomedicines10071736
Abstract: Diabetes is the ninth leading cause of death, with an estimated 1.5 million deaths worldwide. Type 2 diabetes (T2D) results from the body’s ineffective use of insulin and is largely the result of excess body… read more here.
Keywords: gpr26 counteracts; orphan gpr26; monocyte activation; hyperglycemia ... See more keywords