Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646774
Abstract: Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy that can be associated with focal bone erosions. Psoriasis usually precedes the psoriatic arthritis onset by an average of 10 years, but this relation is not yet… read more here.
Keywords: psoriatic cutaneous; monocyte differentiation; bone damage; cutaneous inflammation ... See more keywords
Carbon dioxide attenuates PKC signaling and is sensed in monocytes and macrophages by a CA2-dependent, coupled intracellular pH-response
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734238
Abstract: Background: Increased levels of CO2 reduce macrophage function during inflammatory processes and wound healing. However, little is known how macrophages sense CO2 and adapt upon high levels of CO2 during differentiation and activation. We, therefore,… read more here.
Keywords: levels co2; monocyte differentiation; physiology; intracellular response ... See more keywords
Targeting fatty acid β-oxidation impairs monocyte differentiation and prolongs heart allograft survival
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.151596
Abstract: Monocytes play an important role in the regulation of alloimmune responses after heart transplantation (HTx). Recent studies have highlighted the importance of immunometabolism in the differentiation and function of myeloid cells. While the importance of… read more here.
Keywords: monocyte differentiation; survival; htx; heart ... See more keywords
Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages
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DOI: 10.3389/fimmu.2020.584229
Abstract: Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins… read more here.
Keywords: laminin 511; basement membrane; monocyte differentiation; differentiation ... See more keywords
Monocyte Differentiation and Heterogeneity: Inter-Subset and Interindividual Differences
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108757
Abstract: The three subsets of human monocytes, classical, intermediate, and nonclassical, show phenotypic heterogeneity, particularly in their expression of CD14 and CD16. This has enabled researchers to delve into the functions of each subset in the… read more here.
Keywords: heterogeneity; monocyte differentiation; differences monocyte; heterogeneity inter ... See more keywords