A Zinc‐ and Calcium‐Rich Lysosomal Nanoreactor Rescues Monocyte/Macrophage Dysfunction under Sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205097
Abstract: Sepsis is a dysregulation of the immune response to pathogens and has high morbidity and mortality worldwide. However, the unclear mapping and course of dysregulated immune cells currently hinders the development of advanced therapeutic strategies… read more here.
Keywords: sepsis; monocyte macrophage; calcium; zinc ... See more keywords
Monocyte and macrophage immunometabolism in atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0656-7
Abstract: Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in the development of lipid dense plaques. Chronic inflammation induced by Western-type diet is associated with the risk of developing atherosclerosis, and new… read more here.
Keywords: immunometabolism atherosclerosis; inflammation; monocyte macrophage; macrophage immunometabolism ... See more keywords
Kaempferol impedes IL-32-induced monocyte-macrophage differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.07.010
Abstract: Kaempferol possesses a wide range of therapeutic properties, including antioxidant, anti-inflammatory, and anticancer properties. The present study sought to evaluate the effects and possible pharmacological mechanisms of kaempferol on interleukin (IL)-32-induced monocyte-macrophage differentiation. In this… read more here.
Keywords: kaempferol; macrophage differentiation; monocyte macrophage; macrophage ... See more keywords
Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.05.106
Abstract: BACKGROUND We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. METHODS Serum monocyte/macrophage and T cell activation markers soluble (s)… read more here.
Keywords: risk; macrophage cell; monocyte macrophage; cell activation ... See more keywords
In vivo Monocyte/Macrophage-hitchhiked Intratumoral Accumula-tion of Nanomedicines for Enhanced Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11046
Abstract: The inner region of solid tumors is found to be high-pressure, hypoxic and immunosuppressive, providing a breeding ground for tumor aggressiveness and metastasis. While intratumoral accumulation of nanomedicines combined with immuno-modulation would significantly enhance therapeutic… read more here.
Keywords: intratumoral accumula; macrophage hitchhiked; vivo monocyte; hitchhiked intratumoral ... See more keywords
sTim-3 alleviates liver injury via regulation of the immunity microenvironment and autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-00299-7
Abstract: Liver failure (LF) is a monocyte/macrophage-mediated liver injury that has been associated with inflammatory mediators. However, the mechanism through which monocytes/macrophages regulate LF has not been fully elucidated. In this study, we investigated the role… read more here.
Keywords: stim; liver injury; monocyte macrophage;
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Nature immunology"
DOI: 10.1038/s41590-021-00928-y
Abstract: Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark in human peripheral blood monocytes is… read more here.
Keywords: proteolytic cleavage; monocyte macrophage; repression; differentiation ... See more keywords
Decreases in markers of monocyte/macrophage activation after hepatitis C eradication in HIV/HCV co-infected women.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS"
DOI: 10.1097/qad.0000000000002869
Abstract: OBJECTIVE Eradication of hepatitis C virus (HCV) in HIV disease decreases liver and non-liver-related morbidity and mortality. Elevated markers of monocyte/macrophage activation (soluble CD163 and sCD14) are associated with excess non-AIDS morbidity and mortality in… read more here.
Keywords: eradication; hiv; monocyte macrophage; macrophage activation ... See more keywords
Angiotensin II–C–C chemokine receptor2/5 axis‐dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12548
Abstract: Angiotensin II (ANG II) plays critical roles in modulation of circulatory homeostasis and activation of innate and adaptive immunity and has also been implicated in several mouse models of autoimmune disease. However, how ANG II… read more here.
Keywords: autoimmune myocarditis; macrophage recruitment; monocyte macrophage; macrophage ... See more keywords
Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0588
Abstract: The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determine their connections to… read more here.
Keywords: tumor monocyte; monocyte macrophage; kidney cancer; differentiation ... See more keywords
Crohn’s Disease Patients with Depression Exhibit Alterations in Monocyte/Macrophage Phenotype and Increased Proinflammatory Cytokine Production
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases"
DOI: 10.1159/000501122
Abstract: Background: Crohn’s disease (CD) is strongly associated with depression, but the mechanisms underlying this relationship are not fully understood. Recently, neuroimmunological studies have demonstrated that proinflammatory monocytes/macrophages play a key role in the pathogenesis of… read more here.
Keywords: cytokine; disease; monocyte macrophage; macrophage ... See more keywords