Abstract Tu0046: Cholesterol-mTOR Nexus: Dissecting the Impact of Hypercholesterolemia in Lysosomal Dysfunction
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.tu0046
Abstract: Introduction: Atherosclerosis is the primary cause of death globally. During atherosclerosis, cholesterol in arterial walls triggers inflammation, recruiting monocytes and macrophages. These cells show impaired autophagy, creating a hyperinflammatory, proatherogenic state unaddressed by current cholesterol-lowering… read more here.
Keywords: cholesterol; mtorc1; monocyte mtorc1; apoptosis ... See more keywords
Abstract 4339402: Cholesterol-Driven Monocyte mTORC1 Activation and Autophagy Suppression in Hypercholesterolemic Patients: A Translational Link to Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4339402
Abstract: Background: While statin therapy effectively lowers plasma LDL cholesterol (LDL-C), residual cardiovascular risk remains. Emerging evidence suggests that LDL-C may exert deleterious effects beyond its role in plaque development. Even moderately elevated or borderline LDL-C… read more here.
Keywords: hypercholesterolemic patients; mtorc1; mtor; monocyte mtorc1 ... See more keywords