INFβ treatment affects global DNA methylation in monocytes of patients with multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577563
Abstract: The combination of genetic and epigenetic influences alters the development of complex diseases. Aberrant patterns of DNA methylation are associated with inflammation and clinical activity in MS. We evaluated the differences between global DNA methylation… read more here.
Keywords: methylation; monocytes patients; treatment; global dna ... See more keywords
Meta-inflammation in monocytes of patients with Acute Coronary Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.1568
Abstract: Several studies suggest that an alteration of monocyte metabolism might be implicated in inflammatory diseases. Enhanced glycolysis might be a hallmark of pro-inflammatory monocyte subsets. Improved glycolysis enables the immune cells to generate sufficient ATP… read more here.
Keywords: pkm; glycolysis; monocytes patients; metabolism ... See more keywords
MO592INTERLEUKIN-1A (IL-1A) IS A CENTRAL REGULATOR OF INFLAMMATION IN CARDIOVASCULAR AND KIDNEY DISEASES
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab089.005
Abstract: Cardiovascular diseases (CVD) and chronic kidney disease (CKD) are highly prevalent, aggravate each other, and account for substantial mortality. Both conditions are characterized by activation of the innate immune system. The alarmin IL-1α is expressed… read more here.
Keywords: mo592interleukin central; surface; adhesion; monocytes patients ... See more keywords
Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP‐43 subcellular distribution
Sign Up to like & getrecommendations! Published in 2017 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12328
Abstract: Cytoplasmic accumulation of the nuclear protein transactive response DNA‐binding protein 43 (TDP‐43) is an early determinant of motor neuron degeneration in most amyotrophic lateral sclerosis (ALS) cases. We previously disclosed this accumulation in circulating lymphomonocytes… read more here.
Keywords: monocytes patients; amyotrophic lateral; gene; lateral sclerosis ... See more keywords
Impaired Akt Phosphorylation in Monocytes of Patients with Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12521
Abstract: It has been proposed that the Akt kinase pathway provides a regulatory mechanism to limit the inflammatory response. We examined the activation of Akt upon lipopolysaccharide (LPS) challenge in monocytes of patients with rheumatoid arthritis… read more here.
Keywords: monocytes patients; akt phosphorylation; rheumatoid arthritis; activation ... See more keywords
Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2018-316888
Abstract: Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocytes whereby patients become highly susceptible to bacterial infections. Here, we identify the pathways underlying monocyte dysfunction in ACLF and we investigate whether metabolic rewiring… read more here.
Keywords: monocytes patients; glutamine synthetase; inflammatory capacity; capacity ... See more keywords
Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154183
Abstract: Severe COVID-19 disease is associated with dysregulation of the myeloid compartment during acute infection. Survivors frequently experience long-lasting sequelae, but little is known about the eventual persistence of this immune alteration. Herein, we evaluated TLR-induced… read more here.
Keywords: severe covid; patients acute; acute convalescent; monocytes patients ... See more keywords
Genetic Mutational Profile Influences the Morphological Characteristics of Abnormal Monocytes in Patients with Juvenile Myelomonocytic Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-207038
Abstract: Juvenile myelomonocytic leukemia (JMML) is characterized by excessive myelomonocytic cell proliferation and hypersensitivity to granulocyte-macrophage colony-stimulating factor. Five canonical RAS pathway gene mutations (PTPN11, NF1, KRAS, NRAS, and CBL) are known to be involved in… read more here.
Keywords: jmml; morphological characteristics; type monocytes; monocytes patients ... See more keywords
Increased Circulating CD14+ Monocytes in Patients with Psoriatic Arthritis Presenting Impaired Apoptosis Activity
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12040775
Abstract: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis primarily affecting peripheral and axial joints. The osteolytic effect in the damaged joint is mediated by osteoclast activation. We aimed to investigate differential gene expression in peripheral… read more here.
Keywords: peripheral cd14; psoriatic arthritis; cd14 monocytes; monocytes patients ... See more keywords