Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24412-1
Abstract: Unrelated cord blood transplantation (UCBT) is an effective treatment for hematopoietic disorders. However, this attractive approach is frequently accompanied by pre-engraftment syndrome (PES), severe cases of PES are associated with enhanced mortality and morbidity, but… read more here.
Keywords: engraftment syndrome; pathology; pre engraftment; monocytes promote ... See more keywords
Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.64033
Abstract: Rationale: Monocytes belong to the mononuclear phagocyte system and are immune responders to tissue injury and infection. There were also reports of monocytes transforming to microglia-like cells. Here we explore the roles of monocytes in… read more here.
Keywords: hypoxic ischemic; brain; ischemic brain; monocytes promote ... See more keywords