The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.07.029
Abstract: The continued use of platinum-based chemotherapeutic drugs in the clinic mandates the need for further investigation of the biological activity of structural analogues of the clinically approved complexes. Of interest are monofunctional platinum(II) complexes, which… read more here.
Keywords: platinum; monofunctional platinum; ethane diamine; ligand ... See more keywords
DNA topoisomerases as additional targets for anticancer monofunctional platinum(II) complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt02608e
Abstract: Topoisomerases are ubiquitous enzymes and important targets for DNA-oriented anticancer drugs. Two mitochondrion-targeted monofunctional platinum(ii) complexes, [Pt(ortho-PPh3CH2Py)(NH3)2Cl](NO3)2 (OPT) and [Pt(para-PPh3CH2Py)(NH3)2Cl](NO3)2 (PPT; PPh3 = triphenylphosphonium, Py = pyridine), show significant inhibition towards the activity of DNA… read more here.
Keywords: monofunctional platinum; dna topoisomerases; dna; platinum complexes ... See more keywords
Monofunctional Platinum(II) Anticancer Agents
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DOI: 10.3390/ph14020133
Abstract: Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent… read more here.
Keywords: platinum; monofunctional platinum; anticancer agents; anticancer ... See more keywords