Efficacy and Safety of Janus Kinase Inhibitors in Type I Interferon-Mediated Monogenic Autoinflammatory Disorders: A Scoping Review
Sign Up to like & getrecommendations! Published in 2021 at "Dermatology and Therapy"
DOI: 10.1007/s13555-021-00517-9
Abstract: Type I interferon (IFN)-mediated monogenic autoinflammatory disorders (interferonopathies) are childhood-onset rare multisystemic diseases with limited treatment options. The Janus kinase (JAK) inhibitors are promising potential therapeutic candidates for immune-mediated chronic inflammatory skin diseases. To review… read more here.
Keywords: type interferon; mediated monogenic; monogenic autoinflammatory; safety ... See more keywords
The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation
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DOI: 10.1038/ni.3777
Abstract: Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and immunological entities caused by dysregulation in the innate immune system. Since then, advances in genomic techniques have led to the identification of… read more here.
Keywords: diseases define; monogenic autoinflammatory; autoinflammatory diseases; new pathways ... See more keywords
Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab419
Abstract: OBJECTIVES To investigate survival of interleukin (IL)-1 inhibitors in monogenic autoinflammatory disorders (mAID) through drug retention rate (DRR) and identify potential predictive factors of drug survival from a real-life perspective. PATIENTS AND METHODS Multicentre retrospective… read more here.
Keywords: anakinra canakinumab; drug survival; treatment; monogenic autoinflammatory ... See more keywords
Current Therapeutic Options for the Main Monogenic Autoinflammatory Diseases and PFAPA Syndrome: Evidence-Based Approach and Proposal of a Practical Guide
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DOI: 10.3389/fimmu.2020.00865
Abstract: Monogenic autoinflammatory diseases are rare conditions caused by genetic abnormalities affecting the innate immunity. Previous therapeutic strategies had been mainly based on results from retrospective studies and physicians' experience. However, during the last years, the… read more here.
Keywords: monogenic autoinflammatory; autoinflammatory diseases; autoinflammatory; evidence based ... See more keywords
Central nervous system manifestations of monogenic autoinflammatory disorders and the neurotropic features of SARS-CoV-2: Drawing the parallels
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DOI: 10.3389/fped.2022.931179
Abstract: Central nervous system (CNS) involvement in monogenic autoinflammatory disorders (AID) is increasingly recognized and can be life threatening. Therefore, a low threshold to consider CNS disease should be maintained in patients with systemic inflammation. Hyperinflammation… read more here.
Keywords: autoinflammatory disorders; central nervous; covid; monogenic autoinflammatory ... See more keywords
VEXAS syndrome: an adult-onset monogenic autoinflammatory disease with many unanswered questions
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DOI: 10.5114/reum/165994
Abstract: José Hernández-Rodríguez1,2,3,4 ID , Jakub Nieścieruk5 ID , Maria Maślińska4,5 ID 1Clinical Unit of Autoinflammatory Diseases and Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic of Barcelona, Spain 2Institut d'Investigacions Biomèdiques August Pi i… read more here.
Keywords: autoinflammatory; adult onset; syndrome adult; monogenic autoinflammatory ... See more keywords