Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors
Sign Up to like & getrecommendations! Published in 2022 at "Biological psychiatry"
DOI: 10.1016/j.biopsych.2022.01.018
Abstract: Neuronal circuits within the hypothalamus play a critical role in the homeostatic regulation of body weight. By disrupting the development or function of these circuits, human monogenic disorders cause hyperphagia (increased food intake), neuroendocrine abnormalities,… read more here.
Keywords: syndromes provide; regulation; obesity; monogenic obesity ... See more keywords
Monogenic Obesity; Using Drugs to Bypass the Problem.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.015
Abstract: Safe and effective pharmacological treatments for severe obesity remain scarce. In this issue of Cell Metabolism, Iepsen et al. (2018) show that obese patients with pathogenic melanocortin 4 receptor mutations, the most common form of monogenic… read more here.
Keywords: obesity using; drugs bypass; bypass problem; using drugs ... See more keywords
Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/s41366-018-0049-6
Abstract: Objective:To evaluate whether early childhood body mass index (BMI) is an appropriate indicator for monogenic obesity.Methods:A cohort of n = 21 children living in Germany or Austria with monogenic obesity due to congenital leptin deficiency (group LEP,… read more here.
Keywords: bmi; leptin; monogenic obesity; receptor ... See more keywords
Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI‐SDS—A case series
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Obesity"
DOI: 10.1111/ijpo.12577
Abstract: The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R) gene is characterized by impaired satiety and hyperphagia, leading to extreme, sometimes life‐threatening weight… read more here.
Keywords: lepr; obesity due; mc4r; satiety ... See more keywords
Setmelanotide: A Novel Targeted Treatment for Monogenic Obesity
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DOI: 10.1177/87551225221116010
Abstract: Objective: To review clinical data regarding the newly approved drug setmelanotide, an injectable melanocortin 4 receptor (MC4R) agonist, for chronic weight management in adults and children aged 6 years and older with monogenic obesity. Data… read more here.
Keywords: setmelanotide; obesity setmelanotide; phase; obesity ... See more keywords
The genetic elucidation of monogenic obesity in the Arab world: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0710
Abstract: Abstract Background Investigation of monogenic obesity (MO), a rare condition caused by a single gene variant(s), especially in consanguineous populations, is a powerful approach for obtaining novel insights into the genetic alterations involved. Here, we… read more here.
Keywords: genetic elucidation; systematic review; arab countries; monogenic obesity ... See more keywords