Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.07.007
Abstract: The pathology of Parkinson's disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of misfolded, fibrillar α-synuclein (α-syn). One strategy to slow disease progression is to prevent the misfolding and… read more here.
Keywords: aggregation; inhibits aggregation; enhancing reconfiguration; pathology ... See more keywords
Structural Characteristics of Pneumolysin and Its Domains in a Biomimetic Solution
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01212
Abstract: Pneumolysin (PLY) and its truncated fragments, domains 1–3 (D1–3), and domain 4 (D4), were purified as recombinant proteins after being cloned and over-expressed in Escherichia coli. The three-dimensional structures of these proteins were quantitatively investigated… read more here.
Keywords: ply; structural characteristics; monomeric form; solution ... See more keywords
Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08021-x
Abstract: Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing antibodies toward highly conserved… read more here.
Keywords: conformational modulation; influenza; monomeric form; hemagglutinin ... See more keywords