Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121000
Abstract: Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) with anti-apoptotic and anti-inflammatory properties have been intensively studied. However, rapid clearance by the mononuclear phagocyte system remains a huge barrier for the delivery of extracellular vesicle contents… read more here.
Keywords: extracellular vesicles; heart; cd47; mononuclear phagocyte ... See more keywords
New insights into mononuclear phagocyte biology from the visual system
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.13
Abstract: Major advances in mononuclear phagocyte biology have been made but key questions pertinent to their roles in health and disease remain, including in the visual system. One problem concerns how dendritic cells can trigger immune… read more here.
Keywords: system; phagocyte biology; mononuclear phagocyte; visual system ... See more keywords
Friends or foes: The mononuclear phagocyte system in ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Brain Pathology"
DOI: 10.1111/bpa.13151
Abstract: Ischemic stroke (IS) is a major cause of disability and death in adults, and the immune response plays an indispensable role in its pathological process. After the onset of IS, an inflammatory storm, with the… read more here.
Keywords: phagocyte system; mononuclear phagocyte; ischemic stroke; friends foes ... See more keywords
Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01643
Abstract: The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the… read more here.
Keywords: hrsv; respiratory syncytial; mononuclear phagocyte; phagocyte system ... See more keywords
Intrahepatic infiltration of activated CD8+ T cells and mononuclear phagocyte is associated with idiosyncratic drug-induced liver injury
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1138112
Abstract: Background Idiosyncratic drug-induced liver injury (DILI) is caused by the interplay among drugs, their metabolites, and the host immune response. The characterization of infiltrated immune cells in the liver may improve the understanding of the… read more here.
Keywords: activated cd8; cells mononuclear; liver injury; cd8 cells ... See more keywords
The mononuclear phagocyte system in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i45.6345
Abstract: The mononuclear phagocyte system (MPS) consists of monocytes, dendritic cells and macrophages, which play vital roles in innate immune defense against cancer. Hepatocellular carcinoma (HCC) is a complex disease that is affected or initiated by… read more here.
Keywords: hepatocellular carcinoma; hcc; mononuclear phagocyte; phagocyte system ... See more keywords
Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.38198
Abstract: Rationale: Exosomes are emerging as a promising drug delivery carrier. However, rapid uptake of exosomes by the mononuclear phagocyte system (MPS) remains an obstacle for drug delivery into other targeted organs, including the heart. We… read more here.
Keywords: mononuclear phagocyte; delivery; exosome delivery; uptake exosomes ... See more keywords