Interfacing Polymers and Tissues: Quantitative Local Assessment of the Foreign Body Reaction of Mononuclear Phagocytes to Polymeric Materials
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700021
Abstract: A quantitative method to assess the in vitro foreign body reaction (FBR) of mononuclear phagocytes (MP) to polymers relevant in implants for prosthetics, advanced therapies, and regenerative medicine is presented. It integrates single‐cell force spectroscopy… read more here.
Keywords: mononuclear phagocytes; foreign body; adhesion; body reaction ... See more keywords
In vitro activation and maturation of human mononuclear phagocytes by stimulation with liposomes coated with a neoglycolipid containing α1–3, α1–6-mannotriose
Sign Up to like & getrecommendations! Published in 2019 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-019-09870-6
Abstract: In this study, we assessed the potential of liposomes coated with a neoglycolipid containing α1–3,α1–6-mannotriose residues (Man3-DPPE; Manα1–6(Manα1–3)Manitol-DPPE) for in vitro activation and maturation of human mononuclear phagocytes. In response to treatment with Man3-DPPE-coated liposomes… read more here.
Keywords: mononuclear phagocytes; human mononuclear; man; liposomes coated ... See more keywords
Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.015
Abstract: Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM). In addition, RIPK3 has been shown to regulate NLRP3 inflammasome… read more here.
Keywords: mononuclear phagocytes; cd11c; kinase; ripk3 ... See more keywords
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.08.008
Abstract: Human mononuclear phagocytes comprise phenotypically and functionally overlapping subsets of dendritic cells (DCs) and monocytes, but the extent of their heterogeneity and distinct markers for subset identification remains elusive. By integrating high-dimensional single-cell protein and… read more here.
Keywords: mononuclear phagocytes; circulating inflammatory; single cell; human mononuclear ... See more keywords
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06607-1
Abstract: Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but… read more here.
Keywords: mononuclear phagocytes; peptide toxin; cytolysis; nlrp3 inflammasome ... See more keywords
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
Sign Up to like & getrecommendations! Published in 2021 at "Gut Microbes"
DOI: 10.1080/19490976.2021.1939598
Abstract: ABSTRACT Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope with these usually pro-inflammatory signals… read more here.
Keywords: mononuclear phagocytes; bacterium lactiplantibacillus; commensal bacterium; lactiplantibacillus plantarum ... See more keywords
Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac161
Abstract: AIMS Accumulation of mononuclear phagocytes (monocytes, macrophages and dendritic cells) in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell analysis of mouse and human atherosclerosis, we here aimed to refine the nomenclature… read more here.
Keywords: mouse human; single cell; atherosclerosis; mononuclear phagocytes ... See more keywords
Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1419-2
Abstract: BackgroundAge-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEGF) agents. Placental… read more here.
Keywords: mononuclear phagocytes; vegf; leakage; inhibition ... See more keywords
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure
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DOI: 10.1371/journal.pone.0170781
Abstract: Background Although cardiac and splenic mononuclear phagocytes (MPs), i.e., monocytes, macrophages and dendritic cells (DCs), are key contributors to cardiac remodeling after myocardial infarction, their role in pressure-overload remodeling is unclear. We tested the hypothesis… read more here.
Keywords: mononuclear phagocytes; heart; pressure overload; cardiac remodeling ... See more keywords
Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006462
Abstract: Hantaviruses infect humans via inhalation of virus-contaminated rodent excreta. Infection can cause severe disease with up to 40% mortality depending on the viral strain. The virus primarily targets the vascular endothelium without direct cytopathic effects.… read more here.
Keywords: mononuclear phagocytes; hantavirus; infection; disease ... See more keywords
Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00410
Abstract: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a… read more here.
Keywords: mononuclear phagocytes; bowel disease; inflammatory bowel; disease ... See more keywords