Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase
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DOI: 10.1016/j.heliyon.2020.e03733
Abstract: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in REDOX reactions and oxidative stress defense systems. Furthermore, NAD is used as substrate by proteins that regulate essential cellular functions as DNA repair, genetic, and… read more here.
Keywords: leishmania braziliensis; nicotinamide mononucleotide; braziliensis; lbnmnat protein ... See more keywords
Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)
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DOI: 10.1177/2472555219879644
Abstract: Nicotinamide mononucleotide adenylyltransferase (NMNAT; EC 2.7.7.1) catalyzes the reversible production of NAD+ from NMN+ and ATP and is a potential drug target for cancer and neurodegenerative diseases. A sensitive bioluminescent assay format suitable to high-throughput… read more here.
Keywords: nicotinamide mononucleotide; adenylyltransferase nmnat; throughput screening; bioluminescent ... See more keywords
Localization and phosphorylation of Plasmodium falciparum nicotinamide/nicotinate mononucleotide adenylyltransferase (PfNMNAT) in intraerythrocytic stages
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DOI: 10.1186/s12936-018-2307-4
Abstract: BackgroundNicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT,… read more here.
Keywords: pfnmnat; falciparum; nicotinamide nicotinate; plasmodium falciparum ... See more keywords