Dual Activities of Oxidation and Oxidative Decarboxylation by Flavoenzymes
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DOI: 10.1002/cbic.202100666
Abstract: Specific flavoenzyme oxidases catalyze oxidative decarboxylation in addition to their classical oxidation reactions in the same active sites. The mechanisms underlying oxidative decarboxylation by these enzymes and how they control their two activities are not… read more here.
Keywords: oxidation oxidative; oxidative decarboxylation; monooxygenase; oxidase ... See more keywords
Engineering of a Baeyer‐Villiger monooxygenase to Improve Substrate Scope, Stereoselectivity and Regioselectivity
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DOI: 10.1002/cbic.202400328
Abstract: Baeyer‐Villiger monooxygenases belong to a family of flavin‐binding proteins that catalyze the Baeyer‐Villiger (BV) oxidation of ketones to produce lactones or esters, which are important intermediates in pharmaceuticals or sustainable materials. Phenylacetone monooxygenase (PAMO) from… read more here.
Keywords: baeyer villiger; monooxygenase; baeyer; substrate scope ... See more keywords
Determination of the human cytochrome P450 monooxygenase catalyzing the enantioselective oxidation of 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) and 2,2′,3,4,4′,5′,6-heptachlorobiphenyl (PCB 183)
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0434-z
Abstract: Abstract2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and 2,2′,3,4,4′,5′,6-heptachlorobiphenyl (PCB 183) possess axial chirality and form the aS and aR enantiomers. The enantiomers of these congeners have been reported to accumulate in the human body enantioselectively via unknown mechanisms.… read more here.
Keywords: monooxygenase; pcb heptachlorobiphenyl; pentachlorobiphenyl pcb; heptachlorobiphenyl pcb ... See more keywords
Production of 12-hydroxy dodecanoic acid methyl ester using a signal peptide sequence-optimized transporter AlkL and a novel monooxygenase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioresource technology"
DOI: 10.1016/j.biortech.2019.121812
Abstract: In this study, a signal peptide of AlkL was replaced with other signal peptides to improve the soluble expression and thereby facilitate the transport of dodecanoic acid methyl ester (DAME) substrate into the E. coli.… read more here.
Keywords: monooxygenase; dodecanoic acid; ester; signal peptide ... See more keywords
Peptidylglycine monooxygenase activity of monomeric species of growth hormone
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e02436
Abstract: C-terminal α-amidation of peptides is an important event in the course of pro-hormone and neuropeptide processing; it is a modification that contributes to the biological activity and stability of about 25 peptides in neural and… read more here.
Keywords: monooxygenase activity; monooxygenase; growth hormone; activity ... See more keywords
Catalytically inactive lytic polysaccharide monooxygenase PcAA14A enhances the enzyme-mediated hydrolysis of polyethylene terephthalate.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.09.005
Abstract: The massive accumulation of polyethylene terephthalate (PET) in the global ecosystem is a growing environmental crisis. Development of environmental friendly strategies to achieve enzyme-catalyzed PET degradation has attracted tremendous attention. In this study, we demonstrated… read more here.
Keywords: pet hydrolysis; polyethylene terephthalate; monooxygenase; hydrolysis ... See more keywords
1,4-Dioxane Biodegradation by Mycobacterium dioxanotrophicus PH-06 Is Associated with a Group-6 Soluble Di-Iron Monooxygenase
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Technology Letters"
DOI: 10.1021/acs.estlett.7b00456
Abstract: 1,4-Dioxane (dioxane) is a groundwater contaminant of emerging concern for which bioremediation may be a promising strategy. Several bacterial strains can metabolize dioxane or degrade it cometabolically. However, the molecular basis of dioxane biodegradation is… read more here.
Keywords: iron monooxygenase; monooxygenase; soluble iron; dioxane ... See more keywords
Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface
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DOI: 10.1042/bsr20221102
Abstract: Abstract Gut microbial production of trimethylamine (TMA) from l-carnitine is directly linked to cardiovascular disease. TMA formation is facilitated by carnitine monooxygenase, which was proposed as a target for the development of new cardioprotective compounds.… read more here.
Keywords: escherichia coli; monooxygenase; carnitine monooxygenase; two component ... See more keywords
Genome sequencing and in silico analysis of isoprene degrading monooxygenase enzymes of Sphingobium sp. BHU LFT2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2057360
Abstract: Abstract The whole genome sequencing of a novel isoprene degrading strain of Sphingobium sp. BHU LFT2, its in silico analysis for identifying and characterizing enzymes, especially isoprene monooxygenases (IsoMO), which initiate the degradation process, and… read more here.
Keywords: bhu lft2; monooxygenase; isoprene degrading; isoprene ... See more keywords
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000296
Abstract: Abstract Background: Our previous studies have shown that regulatory factor X5 (RFX5), a classical transcription regulator of MHCII genes, was obviously overexpressed in hepatocellular carcinoma (HCC) tumors. However, the role of RFX5 in the carcinogenesis… read more here.
Keywords: hepatocellular carcinoma; hcc; regulatory factor; monooxygenase ... See more keywords
Role of a FAD-dependent monooxygenase in diazo group functionalization of kinamycin in Streptomyces ambofaciens
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology"
DOI: 10.1101/2024.11.29.626053
Abstract: Kinamycin biosynthesis is a complex process which has been extensively studied over the years, yet specific enzymatic steps continue to be unveiled. A diazo group present in the molecule is responsible for the promising antitumoral… read more here.
Keywords: functionalization kinamycin; streptomyces ambofaciens; monooxygenase; fad dependent ... See more keywords