Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.06.001
Abstract: Flavin-containing monooxygenase 3 (FMO3) is a polymorphic xenobiotic- and dietary compound-metabolizing enzyme associated with the genetic disorder trimethylaminuria. We phenotyped 428 Japanese subjects using traditional urinary phenotyping assays and identified two subjects with read more here.
Keywords: containing monooxygenase; flavin containing; monooxygenase fmo3; database ... See more keywords
Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
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DOI: 10.1371/journal.pone.0187294
Abstract: Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium… read more here.
Keywords: containing monooxygenase; metabolic pathway; flavin containing; tht ... See more keywords