6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells
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DOI: 10.1021/acs.jmedchem.2c01010
Abstract: Thiopurines are in widespread clinical use for the treatment of immunological disorders and certain cancers. However, treatment failure due to resistance or adverse drug reactions are common, asking for new therapeutic strategies. We investigated the… read more here.
Keywords: monophosphate prodrugs; 6sgmp prodrugs; prodrugs display; thioguanosine monophosphate ... See more keywords
Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15020544
Abstract: Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining these… read more here.
Keywords: monophosphate prodrugs; substituted carbocyclic; synthesis substituted; carbocyclic uracil ... See more keywords