Metabolic engineering of Escherichia coli to efficiently produce monophosphoryl lipid A.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2443
Abstract: Monophosphoryl lipid A, mainly isolated from Salmonella minnesota R595, has been used as adjuvant in several vaccines. In this study, an Escherichia coli strain that can efficiently produce the monophosphoryl lipid A has been constructed.… read more here.
Keywords: escherichia coli; monophosphoryl lipid; efficiently produce; mw012 pwepl ... See more keywords
Specific features of human monocytes activation by monophosphoryl lipid A
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25367-y
Abstract: We deciphered the mechanisms of production of pro- and anti-inflammatory cytokines by adherent human blood mononuclear cells (PBMC) activated by lipopolysaccharide (LPS) or monophosphoryl lipid A (MPLA). Both LPS and MPLA induced tumor necrosis factor… read more here.
Keywords: tnf; production; monophosphoryl lipid; mpla ... See more keywords
Monophosphoryl lipid A alleviated radiation‐induced testicular injury through TLR4‐dependent exosomes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14978
Abstract: Radiation protection on male testis is an important task for ionizing radiation‐related workers or people who receive radiotherapy for tumours near the testicle. In recent years, Toll‐like receptors (TLRs), especially TLR4, have been widely studied… read more here.
Keywords: protection; testis; monophosphoryl lipid; radiation ... See more keywords
Monophosphoryl-Lipid A (MPLA) is an Efficacious Adjuvant for Inactivated Rabies Vaccines
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DOI: 10.3390/v11121118
Abstract: Rabies, as one of the most threatening zoonoses in the world, causes a fatal central nervous system (CNS) disease. So far, vaccination with rabies vaccines has been the most effective measure to prevent and control… read more here.
Keywords: rabies vaccines; monophosphoryl lipid; adjuvant inactivated; inactivated rabies ... See more keywords
A Comparison of Intramuscular and Subcutaneous Administration of LigA Subunit Vaccine Adjuvanted with Neutral Liposomal Formulation Containing Monophosphoryl Lipid A and QS21
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DOI: 10.3390/vaccines8030494
Abstract: Leptospirosis vaccines with higher potency and reduced adverse effects are needed for human use. The carboxyl terminal domain of leptospiral immunoglobulin like protein A (LigAc) is currently the most promising candidate antigen for leptospirosis subunit… read more here.
Keywords: administration; monophosphoryl lipid; subunit vaccine; vaccine ... See more keywords
The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia
Sign Up to like & getrecommendations! Published in 2022 at "Anatolian Journal of Cardiology"
DOI: 10.5152/anatoljcardiol.2022.1524
Abstract: Background: Several previous studies have suggested that sublethal doses of Escherichia coli lipopolysaccharide (endotoxin) and monophosphoryl lipid A Re595, a non-pyrogenic derivative of Salmonella minnesota lipopolysaccharide, exhibit antiarrhythmic effects in the rat model of ischemia–reperfusion… read more here.
Keywords: monophosphoryl; monophosphoryl lipid; reperfusion; lipid re595 ... See more keywords