Zinc protects chondrocytes from monosodium iodoacetate-induced damage by enhancing ATP and mitophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.066
Abstract: Osteoarthritis (OA) is characterized with articular cartilage degradation, and monosodium iodoacetate (MIA)-treated chondrocyte is the most commonly used model for mimicking OA progression. Zinc protects chondrocytes from MIA-induced damage. Here, we explored the protective effects… read more here.
Keywords: zinc protects; monosodium iodoacetate; mia; protects chondrocytes ... See more keywords
The therapeutic effects of lipoxin A4 during treadmill exercise on monosodium iodoacetate‐induced osteoarthritis in rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.08.027
Abstract: HIGHLIGHTSLXA4 was rapidly elevated and reduced to normal level after treadmill exercise.There was no difference of LXA4 between moderate and high intensity treadmill exercise.Moderate‐intensity treadmill exercise ameliorate OA could be suppressed by BOC‐2.LXA4 could attenuate… read more here.
Keywords: monosodium iodoacetate; lxa4; treadmill exercise; therapeutic effects ... See more keywords
Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain
Sign Up to like & getrecommendations! Published in 2018 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000685
Abstract: Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to investigate the effects of L-006235, a potent and selective inhibitor of cathepsin K, on pain behaviour and joint… read more here.
Keywords: monosodium iodoacetate; model; pain; pathology ... See more keywords
In vivo protective effects of UCMA against cartilage degeneration in monosodium iodoacetate-induced osteoarthritis model.
Sign Up to like & getrecommendations! Published in 2020 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2020-0009
Abstract: Osteoarthritis (OA) is a degenerative disease affecting the majority of over 65-year-old people and characterized by cartilage degeneration, subchondral abnormal changes and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no… read more here.
Keywords: monosodium iodoacetate; cartilage degeneration; model; degeneration monosodium ... See more keywords
Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats
Sign Up to like & getrecommendations! Published in 2018 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-018-2117-9
Abstract: BackgroundSpinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cartilage cells remains unknown.… read more here.
Keywords: monosodium iodoacetate; induced osteoarthritis; bone; sub chondral ... See more keywords
Effects of oral hyaluronic acid on monosodium iodoacetate-induced osteoarthritis in rats: mechanistic insights and therapeutic implications
Sign Up to like & getrecommendations! Published in 2024 at "Applied Biological Chemistry"
DOI: 10.1186/s13765-024-00945-z
Abstract: This study aimed to meticulously assess the effectiveness of hyaluronic acid (HA) in mitigating symptoms associated with monosodium iodoacetate (MIA)-induced osteoarthritis (OA) symptoms in rodent models and to investigate the underlying mechanistic pathways. Eight-week-old rats… read more here.
Keywords: monosodium iodoacetate; group; hyaluronic acid; induced osteoarthritis ... See more keywords
Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0196625
Abstract: This study aimed to investigate the histopathological changes in the patellofemoral joint using a rat model of osteoarthritis that was induced using monosodium iodoacetate, and to establish a novel model of patellofemoral osteoarthritis in a… read more here.
Keywords: patellofemoral joint; monosodium iodoacetate; model; rat model ... See more keywords
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281135
Abstract: Objective To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for… read more here.
Keywords: delivery systems; osteoarthritis; collagenase type; drug delivery ... See more keywords
Peedanil Gold, Herbo-Mineral Formulation, Moderates Cytokine Levels and Attenuates Pathophysiology in Monosodium Iodoacetate Induced Osteoarthritis in SD Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.883475
Abstract: The inflammatory cartilaginous degeneration of the articular joints, mostly those of knee, hips and hands, is osteoarthritis (OA). The available treatment strategies for osteoarthritis are designed for pain relief, molecular targeting, cartilage regeneration and surgical… read more here.
Keywords: peedanil gold; mineral formulation; herbo mineral; rat model ... See more keywords
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16121885
Abstract: Osteoarthritis (OA) is a chronic degenerative joint disease that causes chronic pain, swelling, stiffness, disability, and significantly reduces the quality of life. Typically, OA is treated using painkillers and non-steroidal anti-inflammatory drugs (NSAIDs). While current… read more here.
Keywords: eggshell membrane; pain; stage; monosodium iodoacetate ... See more keywords
mRNA-Based Combination Therapy for Inflammation-Driven Osteoarthritis Induced by Monosodium Iodoacetate
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17101254
Abstract: Background/Objectives: Osteoarthritis (OA) is a progressive joint disease characterized by inflammation, cartilage degradation, and subchondral bone changes, for which effective disease-modifying therapies are lacking. Messenger RNA (mRNA)-based therapeutics offer a versatile approach to modulate joint… read more here.
Keywords: mrna based; induced monosodium; pathology; monosodium iodoacetate ... See more keywords