Paeonol ameliorates monosodium urate‐induced arthritis in rats through inhibiting nuclear factor‐κB‐mediated proinflammatory cytokine production
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6472
Abstract: Moutan Cortex has been widely used to treat various types of arthritis in traditional Chinese medicine. Paeonol is isolated as an active ingredient from Moutan Cortex. However, the effect and potential mechanism of paeonol on… read more here.
Keywords: induced arthritis; paeonol; rats inhibiting; mia rats ... See more keywords
Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes
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DOI: 10.1007/s10067-021-05676-w
Abstract: We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms by which soluble mediators obtained from activated… read more here.
Keywords: urate crystals; monosodium urate; inflammatory mediators; oxidative stress ... See more keywords
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study
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DOI: 10.1007/s11418-020-01440-7
Abstract: Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not… read more here.
Keywords: dioscin; gouty arthritis; effect; activation ... See more keywords
RETRACTED: Effects of ethanol on monosodium urate crystal-induced inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.03.014
Abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/ article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 3. The corresponding… read more here.
Keywords: retracted effects; article; ethanol monosodium; effects ethanol ... See more keywords
Cynarin suppresses gouty arthritis induced by monosodium urate crystals
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DOI: 10.1080/21655979.2022.2072055
Abstract: ABSTRACT The study is aimed to determine the effects of cynarin (Cyn) on mice with gouty arthritis (GA) induced by monosodium urate (MSU). We measured swelling in the hind paws of mice in vivo using… read more here.
Keywords: hind paws; monosodium urate; induced monosodium; gouty arthritis ... See more keywords
Novel Leflunomide Analog, UTLOH-4e, ameliorates gouty arthritis induced by monosodium urate via NF.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230420101219
Abstract: BACKGROUND Gouty arthritis (GA) is a common form of inflammatory arthritis caused by intra-articular deposition of monosodium urate (MSU) crystals. However, it can not be cured at present. OBJECTIVE The goal of this work was… read more here.
Keywords: monosodium urate; novel leflunomide; arthritis; msu crystals ... See more keywords
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy
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DOI: 10.2337/db18-0912
Abstract: We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found… read more here.
Keywords: diabetic retinopathy; msu; retinal inflammation; monosodium urate ... See more keywords
Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture
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DOI: 10.3389/fimmu.2021.638676
Abstract: Gout is a common inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. This activates the macrophages into a proinflammatory state by inducing NLRP3-dependent interleukin-1β (IL-1β) secretion, resulting in neutrophil… read more here.
Keywords: inflammasome activation; dcr3; activation; nlrp3 inflammasome ... See more keywords
Glucagon-Like Peptide-1 Receptor Regulates Macrophage Migration in Monosodium Urate-Induced Peritoneal Inflammation
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DOI: 10.3389/fimmu.2022.772446
Abstract: Glucagon-like peptide-1 (GLP-1) is an insulinotropic peptide that signals through the GLP-1 receptor (GLP-1R). GLP-1R, therefore, plays a critical role in diabetes and cardiovascular disease. Whether GLP-1R is involved in inflammatory disease such as gout… read more here.
Keywords: like peptide; peptide; glp; glucagon like ... See more keywords
C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00010
Abstract: Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β.… read more here.
Keywords: monosodium urate; production; msu; msu crystals ... See more keywords