Monoterpene indole alkaloids as leads for targeting multidrug resistant cancer cells from the African medicinal plant Tabernaemontana elegans
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry Reviews"
DOI: 10.1007/s11101-019-09615-1
Abstract: Multidrug resistance (MDR) is the main challenge in cancer treatment. Several mechanisms of MDR have been proposed, such as an increased drug efflux due to the overexpression of ABC drug transporter proteins, or a deregulation… read more here.
Keywords: tabernaemontana elegans; monoterpene indole; indole alkaloids; african medicinal ... See more keywords
Monoterpene indole alkaloids in Uncaria rhynchophlly (Miq.) Jacks chinensis and their chemotaxonomic significance
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Systematics and Ecology"
DOI: 10.1016/j.bse.2020.104057
Abstract: Abstract From the Uncaria rhynchophlly (Miq.) Jacks, twelve monoterpene indole alkaloids, such as harman (1), strictosamide (2), vincosidelactam (3), cadambine (4), 3α-dihydrocadambine (5), 7-epi-javaniside (6), rhynchophylline (7), isorhynchophylline (8), hirsutine (9), vincosamide-6′-O-β-D-glucopyranoside (10), vincosamide-11-O-β-D-glucopyranoside (11)… read more here.
Keywords: rhynchophlly miq; miq jacks; monoterpene indole; indole alkaloids ... See more keywords
Monoterpene indole alkaloids from Melodinus cochinchinensis (Lour.) Merr.
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DOI: 10.1016/j.fitote.2021.105118
Abstract: Melodicochinines A - D (1-4), four new monoterpene indole alkaloids (MIAs), along with 21 known ones, were isolated from the stems and twigs of Melodinus cochinchinensis. Their structures were elucidated on the basis of extensive… read more here.
Keywords: monoterpene indole; melodinus cochinchinensis; indole alkaloids; alkaloids melodinus ... See more keywords
Monoterpene indole alkaloids with diverse skeletons from the stems of Rauvolfia vomitoria and their acetylcholinesterase inhibitory activities.
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2020.112450
Abstract: Nine undescribed monoterpene indole alkaloids, rauvomitorine A-I, including an unprecedented C-9-methoxymethylene-sarpagine framework alkaloid, two rare suaveoline framework type alkaloids, and six yohimbine framework type alkaloids, as well as eleven known alkaloids, were isolated from the… read more here.
Keywords: type alkaloids; framework; monoterpene indole; inhibitory activities ... See more keywords
Gelstriamine A, a Triamino Monoterpene Indole Alkaloid with a Caged 6/5/7/6/6/5 Scaffold and Analgesic Alkaloids from Gelsemium elegans Stems.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00062
Abstract: A novel triamino monoterpene indole alkaloid with an unprecedented skeleton, gelstriamine A (1), four new monoterpene indole alkaloids (2-5), and 12 known analogues (6-17) were isolated from Gelsemium elegans. The structures of 1-5 were established… read more here.
Keywords: monoterpene indole; triamino monoterpene; gelsemium elegans; indole alkaloid ... See more keywords
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00092
Abstract: The monoterpene indole alkaloid (MIA) mitragynine has garnered attention as a potential treatment for pain, opioid use disorder, and opioid withdrawal because of its combined pharmacology at opioid and adrenergic receptors in humans. This alkaloid… read more here.
Keywords: mitragyna speciosa; speciosa; mitragyna; mitragynine ... See more keywords