Tocilizumab Monotherapy or Combined With Methotrexate for Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.11095
Abstract: Key Points Question What is the efficacy and safety profile of subcutaneous tocilizumab as monotherapy or in combination with methotrexate for patients with rheumatoid arthritis (RA)? Findings In this randomized clinical trial involving 340 patients,… read more here.
Keywords: monotherapy combination; subcutaneous tocilizumab; rheumatoid arthritis; monotherapy ... See more keywords
Adherence, Persistence, Healthcare Resource Use, and Costs in Tofacitinib-Treated Patients with Psoriatic Arthritis: Data from Two United States Claims Databases
Sign Up to like & getrecommendations! Published in 2024 at "Advances in Therapy"
DOI: 10.1007/s12325-024-02904-y
Abstract: Associations between increased functional disability and higher healthcare resource utilization (HCRU) and costs were reported in patients with psoriatic arthritis (PsA). We assessed characteristics/outcomes of patients with PsA receiving tofacitinib monotherapy vs combination therapy with… read more here.
Keywords: treatment; combination therapy; therapy; monotherapy combination ... See more keywords
Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106512
Abstract: OBJECTIVES . The aim of the present meta-analysis was to compare the clinical and microbiological outcomes of patients treated with beta-lactam monotherapy or combination therapy for Pseudomonas aeruginosa infections. DATA SOURCES MEDLINE, Google Scholar and… read more here.
Keywords: monotherapy combination; therapy; meta analysis;
Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022001081
Abstract: Abstract Abstract From a systematic review framework, we analysed the clinical evidence on the effectiveness and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) treatment. The research protocol was based on the Preferred… read more here.
Keywords: monotherapy combination; chemotherapy chagas; systematic review; chemotherapy ... See more keywords
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Expert review of anticancer therapy"
DOI: 10.1080/14737140.2022.2039123
Abstract: ABSTRACT Introduction Lenvatinib is an oral multitargeted tyrosine kinase inhibitor that has shown efficacy and manageable safety across multiple cancer types. The recommended starting doses for lenvatinib differ across cancer types and indications based on… read more here.
Keywords: monotherapy combination; safety; lenvatinib; efficacy ... See more keywords
Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17573
Abstract: To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution monotherapy and combination therapy after failure of initial monotherapy in people with epilepsy. read more here.
Keywords: monotherapy combination; antiseizure; monotherapy; substitution monotherapy ... See more keywords
IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001647
Abstract: Background Oncolytic viruses (OVs) have shown promise in containing cancer progression in both animal models and clinical trials. How to further improve the efficacy of OVs are intensively explored. Arming OVs with immunoregulatory molecules has… read more here.
Keywords: combination; monotherapy combination; vaccinia virus; tumor ... See more keywords
Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-010006
Abstract: Purpose In this first-in-human dose escalation study, the safety and efficacy of IO-108, a fully human monoclonal antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2), was investigated in patients with advanced solid tumors as monotherapy and… read more here.
Keywords: monotherapy combination; combination; antibody; solid tumors ... See more keywords
First-in-Human Dose-Escalation Study of Fianlimab, an Antilymphocyte Activation Gene-3 Antibody, with Cemiplimab in Patients with Advanced Malignancies
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-23-3883
Abstract: Abstract Purpose: Preclinical data indicate that fianlimab (antilymphocyte activation gene-3) plus cemiplimab (anti–PD-1) enhances antitumor activity. Here, we report prespecified final analyses of the dose-escalation part of a first-in-human, phase 1 study (NCT03005782) of fianlimab… read more here.
Keywords: dose escalation; cemiplimab patients; cemiplimab; monotherapy combination ... See more keywords
Abstract 2494: ATR inhibitor AZD6738 as monotherapy and in combination with olaparib or chemotherapy: defining pre-clinical dose-schedules and efficacy modelling
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2494
Abstract: Introduction: AZD6738 is a potent and selective oral inhibitor of the ataxia telangiectasia and rad3 related (ATR) protein kinase. ATR has a key role in the DNA replication stress response (RSR) pathway of DNA repairby… read more here.
Keywords: combination; inhibitor; azd6738; pre clinical ... See more keywords
Abstract 4547: Characterization of the LAG-3 targeting antibody BI 754111 in monotherapy and in combination with the anti-PD-1 antibody BI 754091
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4547
Abstract: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor involved in maintaining immunological tolerance via regulation of T-cell activation, proliferation and response. Ligand-mediated activation of LAG-3 negatively regulates T-cell activity that is thought to actively contribute… read more here.
Keywords: combination anti; monotherapy combination; lag; antibody ... See more keywords