Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106512
Abstract: OBJECTIVES . The aim of the present meta-analysis was to compare the clinical and microbiological outcomes of patients treated with beta-lactam monotherapy or combination therapy for Pseudomonas aeruginosa infections. DATA SOURCES MEDLINE, Google Scholar and… read more here.
Keywords: monotherapy combination; therapy; meta analysis;
Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022001081
Abstract: Abstract Abstract From a systematic review framework, we analysed the clinical evidence on the effectiveness and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) treatment. The research protocol was based on the Preferred… read more here.
Keywords: monotherapy combination; chemotherapy chagas; systematic review; chemotherapy ... See more keywords
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Expert review of anticancer therapy"
DOI: 10.1080/14737140.2022.2039123
Abstract: ABSTRACT Introduction Lenvatinib is an oral multitargeted tyrosine kinase inhibitor that has shown efficacy and manageable safety across multiple cancer types. The recommended starting doses for lenvatinib differ across cancer types and indications based on… read more here.
Keywords: monotherapy combination; safety; lenvatinib; efficacy ... See more keywords
Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17573
Abstract: To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution monotherapy and combination therapy after failure of initial monotherapy in people with epilepsy. read more here.
Keywords: monotherapy combination; antiseizure; monotherapy; substitution monotherapy ... See more keywords
IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001647
Abstract: Background Oncolytic viruses (OVs) have shown promise in containing cancer progression in both animal models and clinical trials. How to further improve the efficacy of OVs are intensively explored. Arming OVs with immunoregulatory molecules has… read more here.
Keywords: combination; monotherapy combination; vaccinia virus; tumor ... See more keywords
Abstract 2494: ATR inhibitor AZD6738 as monotherapy and in combination with olaparib or chemotherapy: defining pre-clinical dose-schedules and efficacy modelling
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2494
Abstract: Introduction: AZD6738 is a potent and selective oral inhibitor of the ataxia telangiectasia and rad3 related (ATR) protein kinase. ATR has a key role in the DNA replication stress response (RSR) pathway of DNA repairby… read more here.
Keywords: combination; inhibitor; azd6738; pre clinical ... See more keywords
Abstract 4547: Characterization of the LAG-3 targeting antibody BI 754111 in monotherapy and in combination with the anti-PD-1 antibody BI 754091
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4547
Abstract: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor involved in maintaining immunological tolerance via regulation of T-cell activation, proliferation and response. Ligand-mediated activation of LAG-3 negatively regulates T-cell activity that is thought to actively contribute… read more here.
Keywords: combination anti; monotherapy combination; lag; antibody ... See more keywords
Abstract CT031: COM701 demonstrates preliminary antitumor activity as monotherapy and in combination with nivolumab in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-ct031
Abstract: Introduction: COM701 is a novel first-in-class Immune checkpoint inhibitor (ICI) that binds with high affinity to poliovirus receptor related immunoglobulin domain containing (PVRIG) blocking its interaction with its ligand, PVRL2 and regulating the activity of… read more here.
Keywords: solid tumors; combination nivolumab; com701; arm ... See more keywords
Abstract CT040: A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors: Dose escalation study
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct040
Abstract: Background: IO-108 is a fully human IgG4 monoclonal antibody with high affinity and specificity towards LILRB2 (also known as ILT4). It blocks the interaction of LILRB2 with the known ligands for LILRB2, including HLA-G, ANGPTLs,… read more here.
Keywords: monotherapy combination; relapsed refractory; combination; monotherapy ... See more keywords
Abstract CT136: An open-label phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced hematological malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct136
Abstract: Background Inobrodib (CCS1477) is a first in class potent, selective, and orally bioavailable inhibitor of the bromodomains of p300 and CBP, two closely related histone acetyl transferases with oncogenic roles in hematological malignancies. In pre-clinical… read more here.
Keywords: monotherapy combination; combination; efficacy; monotherapy ... See more keywords
Abstract LB198: A first-in-human, open-label, multicenter study of intratumoral SAR441000 (mixture of cytokine encoding mRNAs), as monotherapy and in combination with cemiplimab in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb198
Abstract: Background: SAR441000 is an intratumoral (IT) therapy consisting of a mixture of mRNAs encoding the cytokines IL-12, IFN-α 2b, GM-CSF, and IL-15sushi. SAR441000 is hypothesized to induce a local and systemic immune response with reduced… read more here.
Keywords: monotherapy combination; response; combination cemiplimab; combination ... See more keywords