Efficacy and safety of pembrolizumab monotherapy in patients with advanced thyroid cancer in the phase 2 KEYNOTE‐158 study
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DOI: 10.1002/cncr.34657
Abstract: The authors report results from the thyroid carcinoma cohort of the multicohort phase 2 KEYNOTE‐158 study (NCT02628067), which evaluated pembrolizumab monotherapy in patients with previously treated cancers. read more here.
Keywords: keynote 158; 158 study; phase keynote; pembrolizumab monotherapy ... See more keywords
Efficacy and safety of perampanel monotherapy in patients with focal‐onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open‐label Study 342 (FREEDOM Study)
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DOI: 10.1002/epi4.12398
Abstract: Our study assessed perampanel monotherapy in patients (aged ≥12 years) with focal‐onset seizures (FOS) with or without focal to bilateral tonic‐clonic seizures (FBTCS) in Japan and South Korea. read more here.
Keywords: epilepsy; monotherapy patients; perampanel monotherapy; study ... See more keywords
REAL WORLD OUTCOMES OF OBINUTUZUMAB MONOTHERAPY IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
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DOI: 10.1002/hon.48_2631
Abstract: 1 (PD-1) on total CD4, total CD8 and T helper cells, and cytotoxic T lymphocyte-associated antigen-4 on total CD4 (P=0.010) and regulatory T cells (P read more here.
Keywords: outcomes obinutuzumab; real world; treatment; monotherapy patients ... See more keywords
Therapeutic strategy using low-dose carperitide monotherapy in patients with acute heart failure
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DOI: 10.1007/s00380-020-01635-8
Abstract: Kamiya and colleagues demonstrated that higher systolic blood pressure > 135 mmHg and lower serum creatinine level < 0.795 mg/dL were significant predictors of clinically favorable diuretic response to low-dose human atrial natriuretic peptide carperitide… read more here.
Keywords: heart; low dose; carperitide; monotherapy patients ... See more keywords
The Clinical Value of Decitabine Monotherapy in Patients with Acute Myeloid Leukemia
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DOI: 10.1007/s12325-021-01948-8
Abstract: Decitabine (5-aza-2′-deoxycytidine) is a hypomethylating agent used in the treatment of acute myeloid leukemia (AML). Decitabine inhibits DNA methyltransferases, causing DNA hypomethylation, and limiting the transcription of tumor suppressor genes, leading to gene silencing. Decitabine… read more here.
Keywords: myeloid leukemia; treatment; monotherapy patients; decitabine ... See more keywords
Factors influencing the use of tocilizumab as monotherapy in patients with rheumatoid arthritis in a real-life setting: results at 1 year of the ACT-SOLO study
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DOI: 10.1136/rmdopen-2016-000340
Abstract: Introduction Using a biologic disease-modifying antirheumatic drug (bDMARD) as monotherapy in clinical practice for patients with rheumatoid arthritis (RA) is common and recognised by health authorities although current guidelines recommend to combine them with conventional… read more here.
Keywords: monotherapy patients; disease; study; monotherapy ... See more keywords
Pembrolizumab (P) monotherapy in patients with previously treated metastatic high grade neuroendocrine neoplasms (HG-NENs).
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DOI: 10.1200/jco.2018.36.15_suppl.4104
Abstract: 4104Background: There is currently no standard therapy for metastatic HG-NENs after progression on platinum based therapy and available chemotherapy is of limited benefit. Given the promising activ... read more here.
Keywords: patients previously; monotherapy patients; pembrolizumab monotherapy; treated metastatic ... See more keywords
Acalabrutinib monotherapy in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.7547
Abstract: 7547Background: Acalabrutinib, a highly selective, potent, covalent BTK inhibitor, was assessed as monotherapy in pts with R/R de novo DLBCL. Methods: Eligible pts aged ≥18 y, with ECOG PS ≤2 and confirmed R/R non-germinal center… read more here.
Keywords: acalabrutinib monotherapy; response; dlbcl; monotherapy patients ... See more keywords
Efficacy of weekly vinorelbine monotherapy in patients with lung adenocarcinoma.
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DOI: 10.1200/jco.2018.36.15_suppl.e21157
Abstract: e21157Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers. More than two thirds of patients with NSCLC have inoperable locally advanced tumors or metas... read more here.
Keywords: lung adenocarcinoma; patients lung; monotherapy patients; vinorelbine monotherapy ... See more keywords
Neoadjuvant nivolumab monotherapy in patients with resectable gastric cancer: Preliminary results from a multicenter study.
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DOI: 10.1200/jco.2021.39.15_suppl.4026
Abstract: 4026Background: In recent years, several studies suggest that neoadjuvant treatment improve outcomes of patients with resectable advanced gastric cancer (GC). In addition, nivolumab has demonstrate... read more here.
Keywords: patients resectable; neoadjuvant nivolumab; monotherapy patients; gastric cancer ... See more keywords
Safety and efficacy of amrubicin monotherapy in patients with platinum-refractory metastatic neuroendocrine carcinoma of the gastrointestinal tract: a single cancer center retrospective study
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DOI: 10.2147/cmar.s201048
Abstract: Purpose Patients with gastrointestinal neuroendocrine carcinoma (GI-NEC) have poor prognoses. Although platinum-based combination chemotherapy is commonly used as first-line treatment, the benefit of amrubicin (AMR) and salvage chemotherapy in those who develop platinum-refractory GI-NEC remains… read more here.
Keywords: chemotherapy; platinum refractory; neuroendocrine carcinoma; refractory nec ... See more keywords