The regulation of the protein interaction network by monoubiquitination.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2022.102333
Abstract: The conjugation of a single ubiquitin or monoubiquitination acts as a versatile signal that can have both degradative and non-degradative functions. The latter is of particular interest as emerging evidence indicates that ubiquitin-driven alterations of… read more here.
Keywords: interaction network; regulation protein; interaction; network monoubiquitination ... See more keywords
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06854-2
Abstract: The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and Asx use their DEUBiquitinase ADaptor… read more here.
Keywords: monoubiquitination; bap1; dub; asxls ... See more keywords
The diverse roles of histone 2b monoubiquitination in the life of plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac120
Abstract: Covalent modification of histones is an important tool for gene transcriptional control in eukaryotes, which coordinates growth, development and adaptation to environmental changes. In recent years, an important role for monoubiquitination of histone 2B (H2B)… read more here.
Keywords: histone monoubiquitination; monoubiquitination; roles histone; monoubiquitination life ... See more keywords
Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay9819
Abstract: Monoubiquitination of p120-catenin controls adherens junction dissociation in TGFβ-induced EMT. Disassembly of intercellular junctions is a hallmark of epithelial-mesenchymal transition (EMT). However, how the junctions disassemble remains largely unknown. Here, we report that E3 ubiquitin… read more here.
Keywords: p120 catenin; monoubiquitination; catenin; tgf induced ... See more keywords
Association of clinical severity with FANCB variant type in Fanconi anemia.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019003249
Abstract: Fanconi anemia (FA) is the most common genetic cause of bone marrow failure, and is caused by inherited pathogenic variants in any of 22 genes. Of these, only FANCB is X-linked. We describe a cohort… read more here.
Keywords: monoubiquitination; fancb; fanconi anemia; severity ... See more keywords
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201847563
Abstract: Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly understood. Ferroptosis is a form of non‐apoptotic cell death characterized… read more here.
Keywords: monoubiquitination; regulation ferroptosis; ferroptosis; h2b ... See more keywords
Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201948296
Abstract: Eggless/SETDB1 (Egg), the only essential histone methyltransferase (HMT) in Drosophila, plays a role in gene repression, including piRNA‐mediated transposon silencing in the ovaries. Previous studies suggested that Egg is post‐translationally modified and showed that Windei… read more here.
Keywords: monoubiquitination; transposon silencing; egg; eggless setdb1 ... See more keywords
Overexpression of GmUBC9 Gene Enhances Plant Drought Resistance and Affects Flowering Time via Histone H2B Monoubiquitination
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.555794
Abstract: Ubiquitylation is a form of post-translational modification of proteins that can alter localization, functionality, degradation, or transcriptional activity within a cell. E2 ubiquitin-conjugating enzyme (UBC) and E3 ubiquitin ligases are the primary determinants of substrate… read more here.
Keywords: monoubiquitination; overexpression; soybean; drought ... See more keywords