TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
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DOI: 10.1038/s41467-018-02936-3
Abstract: Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which… read more here.
Keywords: cgas; production; dna; cytosolic dna ... See more keywords