Synthesis of Monovalent N‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.99
Abstract: Ligand‐targeted drug delivery (LTDD) has emerged as an attractive option in the field of oligonucleotide drugs following the great success of N‐acetylgalactosamine (GalNAc)–conjugated siRNA and antisense oligonucleotides. GalNAc is a well‐known ligand of the asialoglycoprotein… read more here.
Keywords: acetylgalactosamine; galnac; moiety; monovalent ... See more keywords
Assembly and inhibitory activity of monovalent mannosides terminated with aromatic methyl esters: The effect of naphthyl groups.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate research"
DOI: 10.1016/j.carres.2017.03.020
Abstract: A series of monovalent α-D-mannoside ligands terminated with aromatic methyl esters have been synthesized in excellent yields using the Cu(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition ("click chemistry"). These mannosides were designed to have a unique aglycone… read more here.
Keywords: methyl; methyl esters; aromatic methyl; monovalent ... See more keywords
Layer-by-layer coatings on ion exchange membranes: Effect of multilayer charge and hydration on monovalent ion selectivities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2018.10.074
Abstract: Electrodialysis (ED) is an important process to desalinate brackish water, which contains scale-forming divalent ions. Hence, there is an interest in separating mono- and divalent ions. In recent years, layer-by-layer (LbL) polyelectrolyte coatings on ion… read more here.
Keywords: coatings ion; monovalent; ion; layer layer ... See more keywords
Alternating current enhanced deposition of a monovalent selective coating for anion exchange membranes with antifouling properties
Sign Up to like & getrecommendations! Published in 2019 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2019.115807
Abstract: Abstract In this work, a monovalent selective anion exchange membrane was prepared by a two-step modification process based on mussel inspired surface chemistry and amide condensation reactions. An alternating current electric field was employed to… read more here.
Keywords: monovalent; monovalent selective; anion exchange; membrane ... See more keywords
Effect of Monovalent Ion Parameters on Molecular Dynamics Simulations of G-Quadruplexes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.7b00257
Abstract: G-quadruplexes (GQs) are key noncanonical DNA and RNA architectures stabilized by desolvated monovalent cations present in their central channels. We analyze extended atomistic molecular dynamics simulations (∼580 μs in total) of GQs with 11 monovalent… read more here.
Keywords: molecular dynamics; water; ion parameters; ion ... See more keywords
7-Metalla-1,4-diphosphanorbornadienes: cycloaddition of monovalent group 13 NacNac complexes to a stable 1,4-diphosphinine.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt01425j
Abstract: This work presents the first example of a dienophilic property of the monovalent group-13 NacNac complexes, which are well-known for their carbene-like reactivity, e.g., addition to multiple bonds, insertion into single bonds, and oxidative cleavage… read more here.
Keywords: monovalent group; cycloaddition; bond; monovalent ... See more keywords
Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain
Sign Up to like & getrecommendations! Published in 2017 at "mAbs"
DOI: 10.1080/19420862.2016.1277301
Abstract: ABSTRACT We developed an IgG1 domain-tethering approach to guide the correct assembly of 2 light and 2 heavy chains, derived from 2 different antibodies, to form bispecific monovalent antibodies in IgG1 format. We show here… read more here.
Keywords: bispecific monovalent; igg1; formation; monovalent ... See more keywords
Structural Characterization and Comparison of Monovalent Cation-Exchanged Zeolite-W
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DOI: 10.3390/ma13173684
Abstract: We report comparative structural changes of potassium-contained zeolite-W (K-MER, structural analogue of natural zeolite merlinoite) and monovalent extra-framework cation (EFC)-exchanged M-MERs (M = Li+, Na+, Ag+, and Rb+). High-resolution synchrotron X-ray powder diffraction study precisely… read more here.
Keywords: cation; group; water molecules; size ... See more keywords