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Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.891
Abstract: To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide variation (SNV), strongly linked with UGT1A3*2, associated…
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Keywords:
comprehensive pharmacogenomic;
important role;
auc0 montelukast;
montelukast pharmacokinetics ... See more keywords
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Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00836-3
Abstract: Dementia with Lewy bodies (DLB) represents a huge medical need as it accounts for up to 30% of all dementia cases, and there is no cure available. The underyling spectrum of pathology is complex and…
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Keywords:
lewy bodies;
dementia lewy;
leukotriene receptor;
pathology ... See more keywords
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Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109134
Abstract: Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. However, various neuropsychiatric events (NEs) suspected to be related to montelukast have been reported recently,…
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Keywords:
hapi sy5y;
hapi cells;
montelukast;
hapi ... See more keywords
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Published in 2020 at "European Journal of Integrative Medicine"
DOI: 10.1016/j.eujim.2019.101028
Abstract: Abstract Introduction Cough variant asthma (CVA) can lead to chronic cough or typical asthma. Though western medications have shown benefit, many patients do not achieve long term effects. Chinese herbal medicine (CHM) has been used…
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Keywords:
medicine;
network meta;
montelukast;
meta analysis ... See more keywords
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Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113657
Abstract: Montelukast is a potent and selective antagonist of the cysteinyl leukotriene receptor 1 subtype (CysLT1) and widely used in the form of oral tablets and granules for asthma prophylaxis and treatment. Recently, due to the…
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Keywords:
simple sensitive;
range;
study;
cell based ... See more keywords
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Published in 2020 at "Powder Technology"
DOI: 10.1016/j.powtec.2019.11.029
Abstract: Abstract In this work, montelukast (MTK) was incorporated in inhalable soft agglomerates (SA) exhibiting inherent characteristics for deep lung deposition while expressing good flowability and enhanced shelf-life stability. Mannitol and ovalbumin were used as particle…
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Keywords:
modified soft;
agglomerate composite;
soft agglomerate;
montelukast ... See more keywords
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Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00261
Abstract: We report the formation and characterization of two diastereomeric thiol-ene addition products of the asthma medication Montelukast within chewing tablets. Widespread tin-based thermal stabilizers dioctyltin bis(2-ethylhexyl thioglycolate) and monooctyltin tris(2-ethylhexyl thioglycolate), used in the manufacturing…
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Keywords:
asthma medication;
ene addition;
thiol ene;
medication ... See more keywords
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Published in 2018 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1466065
Abstract: Abstract Purpose: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas; however, I131 also accumulates in nonthyroidal tissue, which may…
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Keywords:
group administered;
administered rai;
group;
montelukast ... See more keywords
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Published in 2023 at "SLEEP"
DOI: 10.1093/sleep/zsad077.1030
Abstract: Alice in wonderland syndrome (AIWS), also known as Todd’s syndrome, is a neuropsychological condition that causes a set of symptoms with alteration of body image. These distortions include appearing smaller(micropsia) or larger(macropsia) or appearing to…
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Keywords:
alice wonderland;
wonderland rare;
montelukast;
1030 alice ... See more keywords
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Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000740
Abstract: Although the main cause of degeneration of the nigrostriatal dopaminergic (DA) projection in Parkinson’s disease (PD) is still controversial, many reports suggest that excessive inflammatory responses mediated by activated microglia can induce neurotoxicity in the…
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Keywords:
treatment;
montelukast;
microglial activation;
parkinson disease ... See more keywords
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Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.201156
Abstract: Sensitive, simple and green analytical methodology for simultaneous estimation of bambuterol and montelukast as a combined medication based on their native fluorescence character was developed. The method relies on synchronous spectrofluorimetry to solve the problem…
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Keywords:
analysis bambuterol;
simultaneous analysis;
bambuterol montelukast;
quick simultaneous ... See more keywords