Cetuximab Rechallenge Plus Avelumab in Pretreated Patients With RAS Wild-type Metastatic Colorectal Cancer: The Phase 2 Single-Arm Clinical CAVE Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.2915
Abstract: Importance Rechallenge therapy with anti-epidermal growth factor receptor (EGFR) drugs has been suggested in patients with chemo-refractory RAS wild-type (WT) metastatic colorectal cancer (mCRC) after initial response to anti-EGFR-based first-line treatment. The association of treatment… read more here.
Keywords: trial; cetuximab; months months; rechallenge ... See more keywords
Prospective analysis of different combined regimens of stereotactic body radiation therapy and chemotherapy for locally advanced pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1553
Abstract: To identify impacts of different combined regimens of stereotactic body radiation therapy (SBRT) and chemotherapy on survival of patients with locally advanced pancreatic cancer (LAPC) and factors correlated with determinations of different combinations. Four hundred… read more here.
Keywords: chemotherapy; adjuvant chemotherapy; different combined; months months ... See more keywords
Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.
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DOI: 10.1002/cncr.33038
Abstract: BACKGROUND KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways… read more here.
Keywords: patients resected; driver genes; months months; pancreatic ductal ... See more keywords
OUTCOME OF AUTOLOGOUS STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA; EXPERIENCE FROM A SINGLE CENTER IN SAUDI ARABIA
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.240_2631
Abstract: del17p – 5.6% (9/159); 1p32/1q21 amp/del – 12% (19/159); hypodiploidy – 3.1% (5/159); hyperdiploidy – 1.25% (2/159); del5q – 0,6% (1/159); other – not found. Combination two aberrations was discovered in 11.9% (19/159) patients, complex… read more here.
Keywords: risk; risk msmart; median pfs; complex abnormalities ... See more keywords
EVENT FREE SURVIVAL AT 12 MONTHS AND 24 MONTHS AS PREDICTORS FOR OUTCOME OF SYSTEMIC PERIPHERAL T CELL LYMPHOMA: ANALYSIS OF NATIONWIDE THAI LYMPHOMA STUDY GROUP
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.88_2630
Abstract: ysis of Tfh markers, many kinds of Tfh markers in PTCL with Tfhphenotype are less observed than AITL and more than PTCL, NOS. Among clinicopathological features of PTCL with Tfh-phenotype, cases with PS≥2 (P =… read more here.
Keywords: lymphoma; months predictors; months months; survival months ... See more keywords
Gut microbiota correlates with antitumor activity in patients with mCRC and NSCLC treated with cetuximab plus avelumab
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34033
Abstract: Gut microbiota is involved in immune modulation and immune checkpoint inhibitors (ICIs) efficacy. Single‐arm phase II CAVE‐mCRC and CAVE‐LUNG clinical trials investigated cetuximab + avelumab combination in RAS wild‐type (WT) metastatic colorectal cancer (mCRC) and chemo‐refractory nonsmall… read more here.
Keywords: months months; fecal samples; basal fecal; gut microbiota ... See more keywords
Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3761
Abstract: Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age‐ and sex‐dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but… read more here.
Keywords: lipids associated; hepatic lipids; months months; sexual dimorphism ... See more keywords
Drug-Eluting Balloon Angioplasty for Juxta-Anastomotic Stenoses in Distal Radiocephalic Hemodialysis Fistulas: Long-Term Patency Results
Sign Up to like & getrecommendations! Published in 2019 at "CardioVascular and Interventional Radiology"
DOI: 10.1007/s00270-019-02213-w
Abstract: PurposeTo evaluate long-term primary and secondary patency results of drug-eluting balloon angioplasty for the treatment of juxta-anastomotic stenoses in distal radiocephalic arteriovenous fistulas.Materials and MethodsThirty-eight patients with juxta-anastomotic stenotic distal radiocephalic arteriovenous fistulas who underwent… read more here.
Keywords: patency; drug eluting; juxta anastomotic; months months ... See more keywords
The concept of platinum sensitivity could be applied to recurrent cervical cancer: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3402-x
Abstract: PurposeThis study aimed at evaluating the applicability of the concept of platinum sensitivity to recurrent cervical cancer.MethodsThe clinical information of patients with recurrent cervical cancer, who were initially treated with platinum-based chemotherapy and received second-line… read more here.
Keywords: platinum; recurrent cervical; months months; cervical cancer ... See more keywords
[Long-term effectiveness of topical analgesics].
Sign Up to like & getrecommendations! Published in 2019 at "Schmerz"
DOI: 10.1007/s00482-019-00416-1
Abstract: BACKGROUND Neuropathic pain consistently presents a significant therapeutic challenge. Topically applied analgesics have the advantage of showing low systemic side effects, but data on long-term effectiveness are lacking. Consequently, interviews were carried out with all patients… read more here.
Keywords: term; long term; treatment; months months ... See more keywords
A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604)
Sign Up to like & getrecommendations! Published in 2020 at "Gastric Cancer"
DOI: 10.1007/s10120-020-01107-y
Abstract: Background This is a phase 2 study aimed at evaluating the efficacy and safety of TAS-114, a novel deoxyuridine triphosphatase inhibitor, combined with S-1 in patients with advanced gastric cancer (AGC). Methods Eligible patients had… read more here.
Keywords: advanced gastric; gastric cancer; months months; phase study ... See more keywords