3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200432
Abstract: The development of novel μ‐opioid receptor (MOR) antagonists is one of the main objectives of drug discovery and development. Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogs were designed, synthesized, and evaluated… read more here.
Keywords: mor antagonists; phenalkylamino cyclohexyl; silico; mor ... See more keywords
Passivating Oxygen Evolution Activity of NiFe-LDH through Heterostructure Engineering to Realize High-Efficiency Electrocatalytic Formate and Hydrogen Co-Production.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202208027
Abstract: An electrocatalytic methanol oxidation reaction (MOR) is proposed to replace oxygen evolution reaction (OER) in water electrolysis owing to the favorable thermodynamics of MOR than OER. However, there is still a competition between the MOR… read more here.
Keywords: activity nife; oxygen evolution; nife ldh; mor ... See more keywords
Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03595-8
Abstract: μ-opioid receptor (MOR) is a class of opioid receptors that is critical for analgesia, reward, and euphoria. MOR is distributed in various brain regions, including the hippocampus, where traditionally, it is believed to be localized… read more here.
Keywords: opioid receptor; hippocampus; mor; receptor mor ... See more keywords
Increased cocaine reward in offspring of females exposed to morphine during adolescence
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5132-0
Abstract: RationaleA growing body of evidence demonstrates that environmental exposures can impact the physiology and behavior of subsequent generations. We have previously demonstrated reduced morphine self-administration in the F1 and F2 offspring of female rats exposed… read more here.
Keywords: exposed morphine; mor; acute cocaine; physiology ... See more keywords
Enhanced Catalytic Performance of Cr/MOR for Ethane Dehydrogenation Through Dealumination
Sign Up to like & getrecommendations! Published in 2020 at "Catalysis Letters"
DOI: 10.1007/s10562-020-03421-7
Abstract: Abstract Dehydrogenation of ethane to ethylene assisted by CO 2 was investigated over CrO x catalysts supported on MOR zeolites. The catalysts were characterized by XRD, N 2 adsorption, SEM, 27 Al and 29 Si… read more here.
Keywords: ethane; dehydrogenation; mor; catalytic performance ... See more keywords
Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2286-9
Abstract: The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action in a battery of preclinical pain models in adult male CF#1 mice (formalin, writhing, and tail flick) and… read more here.
Keywords: antinociceptive antidepressant; antiseizure antinociceptive; mor; tgb ... See more keywords
Oxygen vacancies confined in ultrathin nickel oxide nanosheets for enhanced electrocatalytic methanol oxidation
Sign Up to like & getrecommendations! Published in 2019 at "Applied Catalysis B: Environmental"
DOI: 10.1016/j.apcatb.2018.12.038
Abstract: Abstract Owing to the relatively sluggish charge transport and reaction kinetics in nickel-based oxides, the electrocatalytic efficiency for methanol oxidation reaction (MOR) is still far below what is expected. Herein, ultrathin NiO nanosheets with abundant… read more here.
Keywords: oxygen; oxygen vacancies; methanol oxidation; mor ... See more keywords
Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2020.07.051
Abstract: BACKGROUND Expression of the mu-opioid receptor (MOR) is associated with poor long-term outcomes in various types of cancer. The association between MOR expression and clinical outcomes in laryngeal squamous cell carcinoma (LSCC) is not clear.… read more here.
Keywords: opioid receptor; carcinoma; mor; mor expression ... See more keywords
Antagonists Pharmacologically Chaperone Opioid Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.11.328
Abstract: More than 100 people die daily in the United States from opioid-related drug overdoses. µ-Opioid receptor (MOR) antagonists, such as naltrexone (Ntx) and naloxone, partially suppress overdose effects, but also induce supersensitivity to MOR activation.… read more here.
Keywords: antagonists pharmacologically; mor; opioid receptors; eres levels ... See more keywords
Sex differences in morphine-induced trafficking of mu-opioid and corticotropin-releasing factor receptors in locus coeruleus neurons
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.001
Abstract: The locus coeruleus (LC)-norepinephrine (NE) system is a key nucleus in which endogenous opioid and stress systems intersect to regulate the stress response. LC neurons of male rats become sensitized to stress following chronic morphine… read more here.
Keywords: mor; locus coeruleus; stress; sex ... See more keywords
Isolated zinc in mordenite stabilizing carbonylation of dimethyl ether to methyl acetate
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.05.032
Abstract: Abstract Herein, we prepared a series of H-Zn-mordenite (H-Zn-MOR) catalysts by adding zinc source into the initial sols during the synthesis of mordenite (MOR). The results indicated that isolated Zn ions were highly dispersed in… read more here.
Keywords: methyl acetate; dimethyl ether; ether methyl; zinc ... See more keywords