Delta Opioid Receptors within the Cortico-Thalamic Circuitry Underlie Hyperactivity Induced by High-Dose Morphine.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202503831
Abstract: Hyperactivity is a well-documented neurobehavioral effect of morphine and other opioid drugs, predominantly observed in rodent models, yet the neural circuits and molecular mechanisms underlying this effect remain elusive. In this study, an excitatory projection… read more here.
Keywords: zim; morphine; high dose; dose morphine ... See more keywords
Design of a Long‐Acting Morphine Prodrug for Safe Opioid Delivery
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DOI: 10.1002/cmdc.202500499
Abstract: Effective opioid management in neonatal abstinence syndrome (NAS) and opioid use disorder (OUD) requires maintaining low, stable plasma opioid levels to prevent withdrawal without central side effects. Current treatments rely on frequent opioid dosing, such… read more here.
Keywords: morphine; design long; morphine prodrug; long acting ... See more keywords
Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open‐label, randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2602
Abstract: Benzodiazepines have been used as safe anxiolytic drugs for decades and some authors have suggested they could be an alternative for morphine for treating acute cardiogenic pulmonary oedema (ACPE). We compared the efficacy and safety… read more here.
Keywords: acute cardiogenic; morphine; pulmonary oedema; cardiogenic pulmonary ... See more keywords
The relationship between interhemispheric synchrony, morphine and microstructural development of the corpus callosum in extremely preterm infants
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DOI: 10.1002/hbm.26040
Abstract: The primary aim of this study is to examine whether bursting interhemispheric synchrony (bIHS) in the first week of life of infants born extremely preterm, is associated with microstructural development of the corpus callosum (CC)… read more here.
Keywords: microstructural development; extremely preterm; synchrony; preterm infants ... See more keywords
Exploring neuroadaptive cellular pathways in chronic morphine exposure: An in‐vitro analysis of cabergoline and Mdivi‐1 co‐treatment effects on the autophagy–apoptosis axis
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DOI: 10.1002/jcb.30558
Abstract: The complex impacts of prolonged morphine exposure continue to be a significant focus in the expanding area of addiction studies. This research investigates the effectiveness of a combined treatment using Cabergoline and Mdivi‐1 to counteract… read more here.
Keywords: morphine; treatment; apoptosis; cabergoline mdivi ... See more keywords
Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10094
Abstract: Early life stress (ELS) disrupts brain development and subsequently affects physical and psychological health. ELS has been associated with an increased risk of relapse and inadequate treatment response in addicted patients. The current study was… read more here.
Keywords: morphine; agonist; rewarding effect; effect ... See more keywords
Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats
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DOI: 10.1002/jdn.10251
Abstract: Maternal morphine exposure reduces motivation for basic cognitive tasks, followed by executive function deficits in attention and accuracy. It also induces depression‐like behaviors and has negative consequences for learning and memory in offspring. Interaction between… read more here.
Keywords: morphine; locomotor activity; morphine exposure;
Comparative evaluation of the sedative and physiological effects of medetomidine alone and in combination with pethidine, morphine, tramadol, and methadone in goats
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DOI: 10.1002/vms3.806
Abstract: Abstract Background The use of combinations of α2‐adrenergic agonists and opioids has been published as providing superior sedation than either drug alone. Introduction The present study aims to compare the sedative and physiological effects of… read more here.
Keywords: morphine; medetomidine; combination; methadone ... See more keywords
TRPV1 channel antagonist capsazepine alleviates morphine tolerance and morphine-induced neurotoxicity by preventing mitochondrial damage and apoptosis: an in vivo and in vitro study
Sign Up to like & getrecommendations! Published in 2025 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-025-04384-5
Abstract: Morphine is one of the drugs frequently used for severe pain in chronic diseases such as cancer, but long-term use leads to morphine tolerance. The mechanism of morphine tolerance is not yet fully understood. This… read more here.
Keywords: tolerance; morphine; morphine induced; trpv1 channel ... See more keywords
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05650-5
Abstract: Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co-administration of cannabinoids with opioid receptor agonists produce anti-nociceptive synergy, but… read more here.
Keywords: opioid receptor; morphine; anti nociceptive; receptor ... See more keywords
Co-administration of nalbuphine attenuates the morphine-induced anxiety and dopaminergic alterations in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05765-3
Abstract: INTRODUCTION The classical effects of exogenous opioids, such as morphine, are predominantly mediated through μ-opioid receptors. The chronic use of morphine induces anxiety-like behavior causing functional changes in the mesolimbic dopaminergic system. The mixed μ/κ-agonist,… read more here.
Keywords: morphine induced; morphine; induced anxiety; anxiety ... See more keywords