Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open‐label, randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2602
Abstract: Benzodiazepines have been used as safe anxiolytic drugs for decades and some authors have suggested they could be an alternative for morphine for treating acute cardiogenic pulmonary oedema (ACPE). We compared the efficacy and safety… read more here.
Keywords: acute cardiogenic; morphine; pulmonary oedema; cardiogenic pulmonary ... See more keywords
The relationship between interhemispheric synchrony, morphine and microstructural development of the corpus callosum in extremely preterm infants
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26040
Abstract: The primary aim of this study is to examine whether bursting interhemispheric synchrony (bIHS) in the first week of life of infants born extremely preterm, is associated with microstructural development of the corpus callosum (CC)… read more here.
Keywords: microstructural development; extremely preterm; synchrony; preterm infants ... See more keywords
Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10094
Abstract: Early life stress (ELS) disrupts brain development and subsequently affects physical and psychological health. ELS has been associated with an increased risk of relapse and inadequate treatment response in addicted patients. The current study was… read more here.
Keywords: morphine; agonist; rewarding effect; effect ... See more keywords
Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10251
Abstract: Maternal morphine exposure reduces motivation for basic cognitive tasks, followed by executive function deficits in attention and accuracy. It also induces depression‐like behaviors and has negative consequences for learning and memory in offspring. Interaction between… read more here.
Keywords: morphine; locomotor activity; morphine exposure;
Comparative evaluation of the sedative and physiological effects of medetomidine alone and in combination with pethidine, morphine, tramadol, and methadone in goats
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DOI: 10.1002/vms3.806
Abstract: Abstract Background The use of combinations of α2‐adrenergic agonists and opioids has been published as providing superior sedation than either drug alone. Introduction The present study aims to compare the sedative and physiological effects of… read more here.
Keywords: morphine; medetomidine; combination; methadone ... See more keywords
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05650-5
Abstract: Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co-administration of cannabinoids with opioid receptor agonists produce anti-nociceptive synergy, but… read more here.
Keywords: opioid receptor; morphine; anti nociceptive; receptor ... See more keywords
Co-administration of nalbuphine attenuates the morphine-induced anxiety and dopaminergic alterations in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05765-3
Abstract: INTRODUCTION The classical effects of exogenous opioids, such as morphine, are predominantly mediated through μ-opioid receptors. The chronic use of morphine induces anxiety-like behavior causing functional changes in the mesolimbic dopaminergic system. The mixed μ/κ-agonist,… read more here.
Keywords: morphine induced; morphine; induced anxiety; anxiety ... See more keywords
The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine
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DOI: 10.1007/s00414-017-1754-8
Abstract: In forensic medicine, expert opinion is often required concerning dose and time of intake of a substance, especially in the context of fatal intoxications. In the present case, a 98-year-old man died 4 days after admission… read more here.
Keywords: medicine; based pharmacokinetic; morphine; physiologically based ... See more keywords
Oral morphine drops for prompt relief of breathlessness in patients with advanced cancer—a randomized, double blinded, crossover trial of morphine sulfate oral drops vs. morphine hydrochloride drops with ethanol (red morphine drops)
Sign Up to like & getrecommendations! Published in 2019 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-019-05116-1
Abstract: Purpose Episodic breathlessness is frequent in palliative cancer patients. Opioids are the only pharmacological agents with sufficient evidence in treatment. In Denmark, the main recommendation is red morphine drops (RMD), an off-label solution of morphine,… read more here.
Keywords: breathlessness; trial; morphine; crossover ... See more keywords
Intra-accumbal Cannabinoid Agonist Attenuated Reinstatement but not Extinction Period of Morphine-Induced Conditioned Place Preference; Evidence for Different Characteristics of Extinction Period and Reinstatement
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DOI: 10.1007/s11064-017-2374-x
Abstract: The brain reward system consists of the ventral tegmental area that sends its dopaminergic projections to the forebrain, cortical areas, amygdala and largely to the nucleus accumbens (NAc). The present study aims were to investigate… read more here.
Keywords: reinstatement; morphine; extinction; extinction period ... See more keywords
Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells
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DOI: 10.1007/s12012-018-9448-0
Abstract: There are some indications that morphine may exert myocardial protective effects under certain conditions. The aim of the present study was to investigate the effect of morphine on viability and oxidative state of H9c2 cells… read more here.
Keywords: morphine; h9c2 cells; effect morphine; gsk ... See more keywords