Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10251
Abstract: Maternal morphine exposure reduces motivation for basic cognitive tasks, followed by executive function deficits in attention and accuracy. It also induces depression‐like behaviors and has negative consequences for learning and memory in offspring. Interaction between… read more here.
Keywords: morphine; locomotor activity; morphine exposure;
Sex-specific transgenerational effects of morphine exposure on reward and affective behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112842
Abstract: Current estimates indicate that millions of people in the United States abuse opioid drugs, which may also affect their offspring. To determine whether parental exposure to morphine alters reward and affective behaviors in subsequent generations… read more here.
Keywords: reward affective; preference; morphine; exposure ... See more keywords
Implication of protein kinase C of the left intermediate medial mesopallium in memory impairments induced by early prenatal morphine exposure in one‐day old chicks
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.12.011
Abstract: ABSTRACT Previously we reported that prenatal morphine exposure during embryonic days 5–8 can cause cognitive deficits of one‐trial passive avoidance learning (PAL) in one‐day old chicks. Because protein kinase C (PKC) has been associated with… read more here.
Keywords: morphine exposure; pkc; prenatal morphine; memory ... See more keywords
Neuroligin‐3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13247
Abstract: Chronic opioid exposure causes structural and functional changes in brain circuits, which may contribute to opioid use disorders. Synaptic cell-adhesion molecules are prime candidates for mediating this opioid-evoked plasticity. Neuroligin-3 (NL3) is an X-linked postsynaptic… read more here.
Keywords: morphine; dopamine neurons; chronic morphine; morphine exposure ... See more keywords
Morphine exposure and neurodevelopmental outcome in infants born extremely preterm.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental medicine and child neurology"
DOI: 10.1111/dmcn.15510
Abstract: AIM To investigate the association between morphine exposure in the neonatal period and neurodevelopment at 2 and 5 years of age while controlling for potential confounders. METHOD We performed a retrospective, single-centre cohort study on 106… read more here.
Keywords: born extremely; extremely preterm; infants born; morphine exposure ... See more keywords
The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00441.2020
Abstract: The infants experience withdrawal from opiates, and time-dependent adaptations in neuronal activity of nucleus accumbens (NAc) may be crucial for this process. A key adaptation is an increased release of acetylcholine. The present study investigates… read more here.
Keywords: morphine; exposure neonatal; morphine exposure; nucleus accumbens ... See more keywords