Co-administration of nalbuphine attenuates the morphine-induced anxiety and dopaminergic alterations in morphine-withdrawn rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05765-3
Abstract: INTRODUCTION The classical effects of exogenous opioids, such as morphine, are predominantly mediated through μ-opioid receptors. The chronic use of morphine induces anxiety-like behavior causing functional changes in the mesolimbic dopaminergic system. The mixed μ/κ-agonist,… read more here.
Keywords: morphine induced; morphine; induced anxiety; anxiety ... See more keywords
Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0780-3
Abstract: Our previous study has proposed that increased presynaptic NMDARs activities play pivotal roles in the development of opioid tolerance and hyperalgesia, and blocking spinal NMDARs attenuates chronic morphine-induced synaptic plasticity and behavior. However, the cellular… read more here.
Keywords: morphine induced; tolerance; tolerance hyperalgesia; hyperalgesia ... See more keywords
Cholinergic M4 receptors are involved in morphine-induced expression of behavioral sensitization by regulating dopamine function in the nucleus accumbens of rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.12.009
Abstract: HIGHLIGHTSMicroinjection of LY2033298 (0.2 &mgr;g/side) into the NAcS blocked the expression of morphine‐induced behavioral sensitization.Tropicamide in the NAcS reversed the inhibitory effect of huperzine‐A on the expression of morphine‐induced behavioral sensitization.SKF38393 in the NAcS reversed… read more here.
Keywords: morphine; expression behavioral; morphine induced; behavioral sensitization ... See more keywords
M3 but not M4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173274
Abstract: Opioids strongly inhibit GABAergic neurons in the rostromedial tegmental nucleus (RMTg) that expresses μ-opioid receptors to induce rewarding and psychomotor effects. M3 and M4 muscarinic receptors are co-localized with μ-opioid receptors at these GABAergic neurons.… read more here.
Keywords: morphine induced; morphine; acquisition morphine; muscarinic receptors ... See more keywords
Intra-accumbal administration of AMN082, a metabotropic glutamate receptor type 7 allosteric agonist, inhibits the acquisition but not the expression of morphine-induced conditioned place preference in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.05.031
Abstract: The nucleus accumbens (NAc) plays a primary role in opioid reward. The actions of glutamate are mediated by the activation of ionotropic and metabotropic glutamate receptors (mGluRs). Previous documents have shown the extensive distributions of… read more here.
Keywords: morphine induced; morphine; expression morphine; induced conditioned ... See more keywords
Uridine attenuates morphine-induced conditioned place preference and regulates glutamate/GABA levels in mPFC of mice
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.10.004
Abstract: Abstract Several lines of evidence suggest that uridine, as a neuromodulator, plays an important role in drug addiction. We previously found that uridine circumvents morphine‐induced behavioral sensitization by decreasing the extracellular dopamine levels in the… read more here.
Keywords: morphine induced; stress induced; stress; glutamate gaba ... See more keywords
Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.12.017
Abstract: HighlightsIntra‐CA1 administration of OX1r antagonist attenuated the expression of morphine‐induced CPP.Intra‐CA1 SB334867 reduced maintenance of morphine rewarding properties in the rats.Blockade of OX1 receptor in CA1 facilitated the extinction of morphine‐induced CPP. &NA; Orexinergic system… read more here.
Keywords: morphine induced; morphine; expression; cpp ... See more keywords
Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.10.011
Abstract: &NA; It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine‐induced CPP is a common method to… read more here.
Keywords: morphine induced; morphine; morphine seeking; induced cpp ... See more keywords
Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105482
Abstract: BACKGROUND AND PURPOSE The aim of this work was to investigate the role and signal transduction of toll-like receptor 4 (TLR4), TGF-β-activated kinase 1 (TAK1) and nod-like receptor protein 3 (NLRP3) in microglial in the… read more here.
Keywords: morphine induced; morphine; tolerance; tak1 ... See more keywords
Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0153-0
Abstract: Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists are a potential option for the treatment of drug addiction. The reinstatement of the addiction can be triggered by environmental stimuli that acquire motivational salience… read more here.
Keywords: morphine induced; expression; mice; dopamine receptor ... See more keywords
Enhancing KCC2 function counteracts morphine-induced hyperalgesia
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DOI: 10.1038/s41598-017-04209-3
Abstract: Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial… read more here.
Keywords: morphine induced; treatment; sdh neurons; enhancing kcc2 ... See more keywords