Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.10.011
Abstract: &NA; It has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine‐induced CPP is a common method to… read more here.
Keywords: morphine induced; morphine; morphine seeking; induced cpp ... See more keywords
Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b01924
Abstract: Innovative discovery strategies are essential to address the ongoing opioid epidemic in the United States. Misuse of prescription and illegal opioids (e.g., morphine, heroin) has led to major problems with addiction and overdose. We used… read more here.
Keywords: seeking behavior; morphine; morphine seeking; preventing morphine ... See more keywords
Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000715
Abstract: Mitragynine (MG) is a pharmacologically active alkaloid derived from the leaves of Mitragyna speciosa Korth (Kratom). This plant has sparked significant interest as a potential alternative treatment for managing opioid dependence and withdrawal due to… read more here.
Keywords: morphine seeking; seeking behaviour; kratom; behaviour rats ... See more keywords