AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.04.020
Abstract: &NA; Development of opioid tolerance and dependence hinders the use of opioids for the treatment of chronic pain. In searching for the mechanism and potential intervention for opioid tolerance and dependence, we studied the action… read more here.
Keywords: dependence; tolerance; positive allosteric; tolerance dependence ... See more keywords
Inflammatory mediators of opioid tolerance: Implications for dependency and addiction
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2019.01.003
Abstract: Each year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged… read more here.
Keywords: tolerance; morphine; development morphine; pain ... See more keywords
Pinocembrin alleviates chronic morphine-induced analgesic tolerance and hyperalgesia by inhibiting microglial activation
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2075656
Abstract: ABSTRACT Background Chronic opioid induced analgesic tolerance is a major obstacle in pain management. Microglial activation is involved in morphine tolerance and pinocembrin suppresses microglial activation in several disease models. We aim to investigate whether… read more here.
Keywords: morphine tolerance; microglial activation; chronic morphine; tolerance ... See more keywords
Spinal heat shock protein 27 participates in PDGFRβ‐mediated morphine tolerance through PI3K/Akt and p38 MAPK signalling pathways
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15169
Abstract: The development of antinociceptive morphine tolerance is a clinically intractable problem. Earlier work has demonstrated the pivotal roles of PDGF and its receptor PDGFRβ in morphine tolerance. Here, we have investigated the role of spinal… read more here.
Keywords: tolerance; spinal heat; heat shock; shock protein ... See more keywords
Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits
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DOI: 10.1371/journal.pone.0253902
Abstract: Background ɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure. Objective The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were… read more here.
Keywords: morphine; tolerance; expression; short term ... See more keywords
Targeting Cytokines for Morphine Tolerance: A Narrative Review
Sign Up to like & getrecommendations! Published in 2019 at "Current Neuropharmacology"
DOI: 10.2174/1570159x15666171128144441
Abstract: Background: Despite its various side effects, morphine has been widely used in clinics for decades due to its powerful analgesic effect. Morphine tolerance is one of the major side effects, hindering its long-term usage for… read more here.
Keywords: targeting cytokines; tolerance narrative; tolerance; cytokines morphine ... See more keywords
Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00072
Abstract: Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis, cancer,… read more here.
Keywords: tolerance; stress; development morphine; morphine tolerance ... See more keywords
Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020233
Abstract: Persistent pain can be managed with opioids, but their use is limited by the onset of tolerance. Ultramicronized N-palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still unclear. Since glial cells are… read more here.
Keywords: morphine tolerance; ultramicronized palmitoylethanolamine; tolerance; pea ... See more keywords
Angiotensin II receptor type 1 blocker candesartan improves morphine tolerance by reducing morphine-induced inflammatory response and cellular activation of BV2 cells via the PPARγ/AMPK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12834
Abstract: Morphine is the most common drug of choice in clinical pain management; however, morphine tolerance presents a significant clinical challenge. The pathogenesis of morphine tolerance is known to be closely associated with angiotensin II receptor… read more here.
Keywords: morphine tolerance; expression levels; candesartan; tolerance ... See more keywords