Morphine use induces gastric microbial dysbiosis driving gastric inflammation through TLR2 signalling which is attenuated by proton pump inhibition
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16025
Abstract: Opioids are the standard drug for pain management; however, their effects on gastric dysfunction are relatively understudied. Opioid users have a higher incidence of gastric pathology leading to increased hospitalization. Herein, we investigated the consequences… read more here.
Keywords: proton pump; pump inhibition; pathology; gastric inflammation ... See more keywords
Morphine Use in ST-Elevation Myocardial Infarction With Downstream P2Y12 Receptor Blockers—Insight From Observational Study
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DOI: 10.1177/10742484221107793
Abstract: Background and Aims: Morphine use for patients presenting with NSTE-ACS is associated with excess mortality. However, the role of morphine in STE-ACS is ill characterized. We have recently confirmed direct prothrombotic effect of morphine using… read more here.
Keywords: morphine; morphine use; downstream p2y12;
High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice
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DOI: 10.3390/brainsci12121650
Abstract: An obvious reason for substance uses disorders (SUDs) is drug craving and seeking behavior induced by conditioned context, which is an abnormal solid context memory. The relationship between susceptibility to SUD and learning ability remains… read more here.
Keywords: ability; learning ability; susceptibility; mice ... See more keywords