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   Articles with "morphogen" as a keyword



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Hedgehog lipids: Promotors of alternative morphogen release and signaling?

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recommendations! Published in 2021 at "BioEssays"

DOI: 10.1002/bies.202100133

Abstract: Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute… read more here.

Keywords: lipids promotors; promotors alternative; morphogen release; alternative morphogen ... See more keywords
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CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

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recommendations! Published in 2018 at "Developmental Cell"

DOI: 10.1016/j.devcel.2017.12.003

Abstract: Summary To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types.… read more here.

Keywords: cell sensitivity; hedgehog; sonic hedgehog; cell ... See more keywords

Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid.

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recommendations! Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.7b00255

Abstract: The morphogenic activity of the Drosophila transcription factor bicoid (Bcd), the first morphogenic protein identified, is controlled by its DNA binding homeodomain. Homeodomains mediate developmental processes in all multicellular organisms, but the Bcd homeodomain appears… read more here.

Keywords: dna; recognition; homeodomain; conformational heterogeneity ... See more keywords

Interpretation of morphogen gradients by a synthetic bistable circuit

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-19098-w

Abstract: During development, cells gain positional information through the interpretation of dynamic morphogen gradients. A proposed mechanism for interpreting opposing morphogen gradients is mutual inhibition of downstream transcription factors, but isolating the role of this specific… read more here.

Keywords: mutual inhibition; circuit; morphogen gradients; interpretation morphogen ... See more keywords

Cell fate decision by a morphogen-transcription factor-chromatin modifier axis

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-50144-z

Abstract: Cell fate decisions remain poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyze molecular details associated with cell fate decisions. Works based on model organisms have provided a conceptual framework of… read more here.

Keywords: fate; morphogen; cell fate; chromatin modifier ... See more keywords

Robust tissue pattern formation by coupling morphogen signal and cell adhesion

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recommendations! Published in 2024 at "EMBO Reports"

DOI: 10.1038/s44319-024-00261-z

Abstract: Morphogens, locally produced signaling molecules, form a concentration gradient to guide tissue patterning. Tissue patterns emerge as a collaboration between morphogen diffusion and responsive cell behaviors, but the mechanisms through which diffusing morphogens define precise… read more here.

Keywords: morphogen gradient; adhesion; morphogen; cell ... See more keywords

Multiple dynamic modes of Bicoid morphogen gradient are explained by a quantum-classical model

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recommendations! Published in 2024 at "AIP Advances"

DOI: 10.1063/5.0221207

Abstract: Extracellular diffusion coupled with degradation is considered a dominant mechanism behind the establishment of morphogen gradients. However, the fundamental nature of these biophysical processes, visa viz, the Bicoid (Bcd) morphogen gradient, remains unclear. Fluorescence correlation… read more here.

Keywords: morphogen gradient; morphogen; dynamic modes; gradient ... See more keywords

Bidirectional transport model of morphogen gradient formation via cytonemes.

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recommendations! Published in 2018 at "Physical biology"

DOI: 10.1088/1478-3975/aaa64c

Abstract: Morphogen protein gradients play an important role in the spatial regulation of patterning during embryonic development. The most commonly accepted mechanism for gradient formation is diffusion from a source combined with degradation. Recently, there has… read more here.

Keywords: gradient formation; transport model; morphogen gradient; morphogen ... See more keywords

Long-range morphogen gradient formation by cell-to-cell signal propagation

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recommendations! Published in 2022 at "Physical Biology"

DOI: 10.1088/1478-3975/ac86b4

Abstract: Morphogen gradients are a central concept in developmental biology. Their formation often involves the secretion of morphogens from a local source, that spread by diffusion in the cell field, where molecules eventually get degraded. This… read more here.

Keywords: cell; morphogen; range; gradient ... See more keywords
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Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.

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recommendations! Published in 2023 at "Journal of cell science"

DOI: 10.1242/jcs.260525

Abstract: Morphogens provide quantitative and robust signaling systems to achieve stereotypic patterning and morphogenesis. Heparan sulfate proteoglycans (HSPGs) are key components of such regulatory feedback networks. In Drosophila, HSPGs serve as co-receptors for a number of… read more here.

Keywords: morphogen pathways; regulation morphogen; morphogen; sulfate proteoglycan ... See more keywords

The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification

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recommendations! Published in 2023 at "PLOS Biology"

DOI: 10.1371/journal.pbio.3002021

Abstract: Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined… read more here.

Keywords: cell; guk holder; morphogen; frazzled guk ... See more keywords