Hedgehog lipids: Promotors of alternative morphogen release and signaling?
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100133
Abstract: Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute… read more here.
Keywords: lipids promotors; promotors alternative; morphogen release; alternative morphogen ... See more keywords
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cell"
DOI: 10.1016/j.devcel.2017.12.003
Abstract: Summary To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types.… read more here.
Keywords: cell sensitivity; hedgehog; sonic hedgehog; cell ... See more keywords
Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00255
Abstract: The morphogenic activity of the Drosophila transcription factor bicoid (Bcd), the first morphogenic protein identified, is controlled by its DNA binding homeodomain. Homeodomains mediate developmental processes in all multicellular organisms, but the Bcd homeodomain appears… read more here.
Keywords: dna; recognition; homeodomain; conformational heterogeneity ... See more keywords
Interpretation of morphogen gradients by a synthetic bistable circuit
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19098-w
Abstract: During development, cells gain positional information through the interpretation of dynamic morphogen gradients. A proposed mechanism for interpreting opposing morphogen gradients is mutual inhibition of downstream transcription factors, but isolating the role of this specific… read more here.
Keywords: mutual inhibition; circuit; morphogen gradients; interpretation morphogen ... See more keywords
Bidirectional transport model of morphogen gradient formation via cytonemes.
Sign Up to like & getrecommendations! Published in 2018 at "Physical biology"
DOI: 10.1088/1478-3975/aaa64c
Abstract: Morphogen protein gradients play an important role in the spatial regulation of patterning during embryonic development. The most commonly accepted mechanism for gradient formation is diffusion from a source combined with degradation. Recently, there has… read more here.
Keywords: gradient formation; transport model; morphogen gradient; morphogen ... See more keywords
Long-range morphogen gradient formation by cell-to-cell signal propagation
Sign Up to like & getrecommendations! Published in 2022 at "Physical Biology"
DOI: 10.1088/1478-3975/ac86b4
Abstract: Morphogen gradients are a central concept in developmental biology. Their formation often involves the secretion of morphogens from a local source, that spread by diffusion in the cell field, where molecules eventually get degraded. This… read more here.
Keywords: cell; morphogen; range; gradient ... See more keywords
Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260525
Abstract: Morphogens provide quantitative and robust signaling systems to achieve stereotypic patterning and morphogenesis. Heparan sulfate proteoglycans (HSPGs) are key components of such regulatory feedback networks. In Drosophila, HSPGs serve as co-receptors for a number of… read more here.
Keywords: morphogen pathways; regulation morphogen; morphogen; sulfate proteoglycan ... See more keywords
The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002021
Abstract: Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined… read more here.
Keywords: cell; guk holder; morphogen; frazzled guk ... See more keywords
Morphogen Signals Shaping the Gastric Glands in Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073632
Abstract: The adult gastric mucosa is characterised by deep invaginations of the epithelium called glands. These tissue architectural elements are maintained with the contribution of morphogen signals. Morphogens are expressed in specific areas of the tissue,… read more here.
Keywords: morphogen; morphogen signals; shaping gastric; gastric glands ... See more keywords
High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue
Sign Up to like & getrecommendations! Published in 2018 at "Nanotheranostics"
DOI: 10.7150/ntno.23354
Abstract: Emerging biomimetic tissue engineering strategies aim to partially recapitulate fundamental events that transpire during embryonic skeletal development; namely, cellular self-organization and targeted morphogenetic pathway activation. Here, we describe self-assembled, scaffold-free human mesenchymal stem cell (hMSC)… read more here.
Keywords: presentation; bmp; tgf bmp; tissue ... See more keywords