Interpretation of morphogen gradients by a synthetic bistable circuit
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DOI: 10.1038/s41467-020-19098-w
Abstract: During development, cells gain positional information through the interpretation of dynamic morphogen gradients. A proposed mechanism for interpreting opposing morphogen gradients is mutual inhibition of downstream transcription factors, but isolating the role of this specific… read more here.
Keywords: mutual inhibition; circuit; morphogen gradients; interpretation morphogen ... See more keywords
Patterning principles of morphogen gradients
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DOI: 10.1098/rsob.220224
Abstract: Metazoan embryos develop from a single cell into three-dimensional structured organisms while groups of genetically identical cells attain specialized identities. Cells of the developing embryo both create and accurately interpret morphogen gradients to determine their… read more here.
Keywords: morphogen gradients; information; principles morphogen; biology ... See more keywords