Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR).
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103578
Abstract: Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding heterocyclic motif with wide ranges of pharmacological activities due to different mechanisms of action. The ability of morpholine to enhance the potency of the… read more here.
Keywords: morpholine ring; chemistry; activity relationship; structure activity ... See more keywords
Revealing quinquennial anticancer journey of morpholine: A SAR based review.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.02.015
Abstract: Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic… read more here.
Keywords: anticancer journey; morpholine; quinquennial anticancer; anticancer ... See more keywords
PET- and ICT-Based Ratiometric Probe: An Unusual Phenomenon of Morpholine-Conjugated Fluorophore for Mitochondrial pH Mapping during Mitophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02177
Abstract: Mitochondrial functions are heavily influenced by acid-base homeostasis. Hence, elucidation of the mitochondrial pH is essential in living cells, and its alterations during pathologies is an interesting question to be addressed. Small molecular fluorescent probes… read more here.
Keywords: pet ict; mitophagy; morpholine; morpholine conjugated ... See more keywords
Morpholine-Stabilized Cationic Aluminum Complexes and Their Reactivity in Ring-Opening Polymerization of ε-Caprolactone.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b00347
Abstract: The first structures exhibiting bidentate (N, O) chelation of a morpholine group to a p-block element (aluminum) have been prepared and characterized by X-ray diffraction methods: Al[L]+ [WCA]-, where [L] = 4-(2-aminoethyl)morpholinylamino- N, N-bis(2-methylene-4,6- tert-butylphenolate)… read more here.
Keywords: group; spectroscopy; aluminum; morpholine ... See more keywords
Rapid and Controlled Organocatalyzed Ring-Opening Polymerization of 3S-(Isobutyl)morpholine-2,5-dione and Copolymerization with Lactide
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecules"
DOI: 10.1021/acs.macromol.0c00940
Abstract: Morpholine-2,5-diones are increasingly attractive monomers derived from amino-acids whose copolymerization with other monomers produces interesting biodegradable materials. In this study, the rapid... read more here.
Keywords: organocatalyzed ring; ring opening; controlled organocatalyzed; rapid controlled ... See more keywords
Dissociative photoionization of heterocyclic molecule-morpholine under VUV synchrotron radiation
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Journal of Chemical Physics"
DOI: 10.1063/1674-0068/cjcp1904068
Abstract: The radiation damage of biomolecules, in particular with aliphatic compound, has been extensively studied. Morpholine is a typical six-membered aliphatic heterocyclic compound. In the present work, photoionization and dissociation of the morpholine monomer and subsequent… read more here.
Keywords: heterocyclic; dissociative photoionization; radiation; amu ... See more keywords
An efficient and scalable process to produce morpholine-d8
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic Communications"
DOI: 10.1080/00397911.2016.1266502
Abstract: ABSTRACT Incorporation of isotopes has long been used as a research tool to label carbons and elucidate biochemical pathways. More recently, H→D exchange has led to analogs of therapeutic agents with improved metabolic stability and… read more here.
Keywords: produce morpholine; scalable process; efficient scalable; process ... See more keywords
Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2018/9670481
Abstract: A reliable derivatization method has been developed to detect and quantify morpholine in apple juices and ibuprofen with gas chromatography-mass spectrometry. Morpholine can react with sodium nitrite under acidic condition to produce stable and volatile… read more here.
Keywords: gas chromatography; mass spectrometry; method; chromatography mass ... See more keywords
Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0170150
Abstract: The Antibiogram properties of 1-chloro-2-isocyanatoethane derivatives of thiomorpholine (CTC), piperazine (CPC) and morpholine (CMC) were evaluated by the approved agar well diffusion, the minimum inhibitory concentration (MIC) and in silico techniques. A total of fourteen… read more here.
Keywords: chloro isocyanatoethane; derivatives thiomorpholine; silico; thiomorpholine piperazine ... See more keywords
Morpholine Based Diazenyl Chalcones: Synthesis, Antimicrobial Screening and Cytotoxicity Study.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666180830152701
Abstract: BACKGROUND Microbial infections have been the major cause of morbidity and mortality for the centuries and continue to present the formidable challenge to the human health. Several studies have been performed to explore the antimicrobial… read more here.
Keywords: cell line; cytotoxicity; diazenyl chalcones; morpholine ... See more keywords
Electron-transfer complexation of morpholine donor molecule with some π – acceptors: Synthesis and spectroscopic characterizations
Sign Up to like & getrecommendations! Published in 2019 at "Polish Journal of Chemical Technology"
DOI: 10.2478/pjct-2019-0043
Abstract: Abstract Morpholine is an interesting moiety that used widely in several organic syntheses. The intermolecular charge-transfer (CT) complexity associated between morpholine (Morp) donor with (monoiodobromide “IBr”, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone “DDQ”, 2,6-dichloroquinone-4-chloroimide “DCQ” and 2,6-dibromoquinone-4-chloroimide “DBQ”) π–acceptors have… read more here.
Keywords: electron transfer; complexation morpholine; transfer complexation; transfer ... See more keywords