Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling
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DOI: 10.1002/advs.202309202
Abstract: The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linked to… read more here.
Keywords: natural product; morphological profiling; aurora kinase; kinase ... See more keywords
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature
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DOI: 10.1101/2022.01.17.476610
Abstract: PROTACs (PROteolysis TArgeting Chimeras) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances in targeted protein degradation technology have been remarkable with several molecules moving into clinical studies. However, robust… read more here.
Keywords: phenotypic signatures; cell; morphological profiling; phenotypic ... See more keywords
Combined neocortical protein and morphological profiling of reactive microglia across Alzheimer’s and Creutzfeldt–Jakob disease
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-025-02163-0
Abstract: Recent RNA-sequencing studies have established a reactive molecular signature and highlighted substantial regional diversity of microglia, underscoring their involvement in neurodegenerative proteinopathies. However, the implications of these findings have not been fully elucidated at the… read more here.
Keywords: disease; jakob disease; morphological profiling; protein ... See more keywords
Systematic morphological profiling of human gene and allele function via Cell Painting
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DOI: 10.7554/elife.24060
Abstract: We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological… read more here.
Keywords: systematic morphological; cell painting; morphological profiling; function ... See more keywords