Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2019.06.011
Abstract: Although several lines of evidence existed suggesting that Mortalin was linked with survival in malignant tumors; it has been barely described regarding the prognostic involvement of its expression in hepatocellular carcinoma (HCC). Herein, to understand… read more here.
Keywords: hepatocellular carcinoma; mortalin correlates; elevated mortalin; mortalin ... See more keywords
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.03.015
Abstract: Mortalin, an essential mitochondrial chaperone protein, is involved in the tumorigenesis of a number of malignancies. This study aimed to investigate the expression of Mortalin in pancreatic ductal adenocarcinoma (PDAC) cells and to determine its… read more here.
Keywords: mortalin; mortalin expression; prognostic significance; pdac ... See more keywords
Abstract 1869: Role of Nef secretion modification region (SMR) peptides and the chaperone mortalin in breast cancer and leukemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1869
Abstract: BACKGROUND: Mortalin/GRP-75(mt-hsp70, HSPA9) is a mitochondrial chaperone protein, also found in the cytoplasm, endoplasmic reticulum and cytoplasmic vesicles. It functions in many cellular processes such as mitochondrial biogenesis, intracellular trafficking, cell proliferation, signaling, immortalization and… read more here.
Keywords: breast cancer; mortalin; smr; cancer ... See more keywords
Identification of Novel Interaction Partners of AIF Protein on the Outer Mitochondrial Membrane
Sign Up to like & getrecommendations! Published in 2018 at "Acta Naturae"
DOI: 10.32607/20758251-2018-10-4-100-109
Abstract: In response to the wide variety of external and internal signals, mammalian cells undergo apoptosis, programmed cell death. Dysregulation of apoptosis is involved in multiple human diseases, including cancer, autoimmunity, and ischemic injuries. Two types… read more here.
Keywords: apoptosis; aif protein; outer mitochondrial; mortalin ... See more keywords
Insights Into the Role of Mortalin in Alzheimer’s Disease, Parkinson’s Disease, and HIV-1-Associated Neurocognitive Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.903031
Abstract: Mortalin is a chaperone protein that regulates physiological functions of cells. Its multifactorial role allows cells to survive pathological conditions. Pharmacological, chemical, and siRNA-mediated downregulation of mortalin increases oxidative stress, mitochondrial dysfunction leading to unregulated… read more here.
Keywords: disease; alzheimer disease; role mortalin; parkinson ... See more keywords