Advances in improving the biotechnological application of oleaginous fungus Mortierella alpina.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11480-y
Abstract: Mortierella alpina is an oleaginous filamentous fungus with considerable lipid productivity, and it has been widely used for industrial production of arachidonic acid. The fermentation process of M. alpina is complicated and can be affected… read more here.
Keywords: improving biotechnological; alpina; fermentation; advances improving ... See more keywords
Bio-enrichment of oilseed cakes by Mortierella alpina under solid-state fermentation
Sign Up to like & getrecommendations! Published in 2020 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2020.109981
Abstract: Abstract Oilseed cakes have potential for new applications as substrates for solid-state fermentation (SSF), to increase their nutritional value by increasing its polyunsaturated fatty acids (PUFAs) or protein content. In this sense, it was performed… read more here.
Keywords: solid state; oilseed cakes; state fermentation; mortierella alpina ... See more keywords
Characterization and Molecular Mechanism of a Novel Cytochrome b5 Reductase with NAD(P)H Specificity from Mortierella alpina.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08108
Abstract: The electron-transfer capabilities of cytochrome b5 reductase (Cyt b5R) and NADPH supply have been shown to be critical factors in microbial fatty acid synthesis. Unfortunately, Cyt b5R substrate specificity is limited to the coenzyme NADH.… read more here.
Keywords: specificity; mortierella alpina; macytb5rii; cytochrome reductase ... See more keywords
Redistributing Carbon Flux by Impairing Saccharide Synthesis to Enhance Lipid Yield in Oleaginous Fungus Mortierella alpina.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.3c00046
Abstract: Increasing carbon flux toward target metabolites is important in improving microbial productivity and economic value. To improve the efficiency of lipid production in Mortierella alpina, we knocked down genes for trehalose-6-phosphate synthetase (Matps) and phosphoenolpyruvate… read more here.
Keywords: yield; carbon flux; mortierella alpina; lipid yield ... See more keywords
Macrophage-targeting oligopeptides from Mortierella alpina
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00860b
Abstract: The realm of natural products of early diverging fungi such as Mortierella species is largely unexplored. Herein, the nonribosomal peptide synthetase (NRPS) MalA catalysing the biosynthesis of the surface-active biosurfactants, malpinins, has been identified and… read more here.
Keywords: mortierella alpina; mortierella; targeting oligopeptides; specificity ... See more keywords
The role of MTHFDL in mediating intracellular lipogenesis in oleaginous Mortierella alpina.
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology"
DOI: 10.1099/mic.0.000897
Abstract: The oleaginous fungus Mortierella alpina can synthesize a variety of polyunsaturated fatty acids, which are used extensively in industry for the production of arachidonic acid (AA). NADPH is the limiting factor and critical reducing agent… read more here.
Keywords: mthfdl; lipogenesis; role; role mthfdl ... See more keywords
Influence of Supplementation of Vegetable Oil Blends on Omega-3 Fatty Acid Production in Mortierella alpina CFR-GV15
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/1432970
Abstract: Objectives of this study were designed for improved production of mycelial omega-3 fatty acids with particular reference to EPA and DHA from the oleaginous fungus Mortierella alpina CFR-GV15 under submerged low temperatures fermentation supplemented with… read more here.
Keywords: alpina cfr; cfr gv15; fatty acid; omega fatty ... See more keywords
An Online Respiratory Quotient-Feedback Strategy of Feeding Yeast Extract for Efficient Arachidonic Acid Production by Mortierella alpina
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2017.00083
Abstract: Mortierella alpina (M. alpina) is well known for arachidonic acid (ARA) production. However, low efficiency and unstableness are long existed problems for industrial production of ARA by M. alpina due to the lack of online… read more here.
Keywords: production; feedback; arachidonic acid; strategy ... See more keywords
Characterization of an Omega-3 Desaturase From Phytophthora parasitica and Application for Eicosapentaenoic Acid Production in Mortierella alpina
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01878
Abstract: Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) have important therapeutic and nutritional benefits in humans. In the biosynthesis pathways of these LC-PUFAs, omega-3 desaturase plays a critical role. In this study, we report a new omega-3… read more here.
Keywords: desaturase; phytophthora parasitica; acid; omega desaturase ... See more keywords
Characterization of NAD+/NADP+-Specific Isocitrate Dehydrogenases From Oleaginous Fungus Mortierella alpina Involved in Lipid Accumulation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.746342
Abstract: Mortierella alpina has a strong capacity for lipid accumulation. Isocitrate dehydrogenase (IDH) plays an important role in affecting the flow of intracellular carbon sources and reducing power NADPH for lipid biosynthesis. In this study, the… read more here.
Keywords: accumulation; lipid accumulation; nad nadp; nad ... See more keywords
The Effect of pH and Temperature on Arachidonic Acid Production by Glycerol-Grown Mortierella alpina NRRL-A-10995
Sign Up to like & getrecommendations! Published in 2018 at "Fermentation"
DOI: 10.3390/fermentation4010017
Abstract: Arachidonic acid (AA) has a wide range of applications in medicine, pharmacology, diet, infant nutrition, and agriculture, due to its unique biological properties. The microbiological processes involved in AA production usually require carbohydrate substrates. In… read more here.
Keywords: production; glycerol; production glycerol; arachidonic acid ... See more keywords