Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.
Sign Up to like & getrecommendations! Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01371-0
Abstract: Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic… read more here.
Keywords: risk; diverse types; hematopoietic mosaic; mosaic chromosomal ... See more keywords
Abstract 3507: Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3507
Abstract: Mosaic mutations in blood are common with increasing age and are prognostic markers for cancer, cardiovascular dysfunction and other diseases. This group of acquired mutations include megabase-scale mosaic chromosomal alterations (mCAs). These large mutations have… read more here.
Keywords: mosaic chromosomal; genome sequencing; mcas; chromosomal alterations ... See more keywords
[Research progress on the epidemiological distribution and influencing factors of autosomal mosaic chromosomal alteration].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"
DOI: 10.3760/cma.j.cn112338-20220715-00632
Abstract: Somatic mosaicism is defined as the occurrence and accumulation of somatic mutations in humans, and mosaic chromosomal alterations (mCA) are recognized as one of the aging phenotypes due to their impact on genome integrity. With… read more here.
Keywords: influencing factors; mosaic chromosomal; factors autosomal; epidemiological distribution ... See more keywords